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hd humpty dumpty [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40642, updated on 8-Feb-2025

Summary

Official Symbol
hdprovided by FlyBase
Official Full Name
humpty dumptyprovided by FlyBase
Primary source
FLYBASE:FBgn0086695
Locus tag
Dmel_CG2669
See related
AllianceGenome:FB:FBgn0086695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2669; Dmel\CG2669; fs(3)272; fs(3)272-9; l(3)82Ff; l(3)82Fk
Summary
Involved in eggshell chorion gene amplification and nuclear DNA replication. Located in nucleus. Is expressed in several structures, including CNS glial cell; antennal primordium; central brain primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in microcephaly, short stature, and limb abnormalities and microcephaly-micromelia syndrome. Orthologous to human DONSON (DNA replication fork stabilization factor DONSON). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

Location:
83A1-83A1; 3-47.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5372592..5374962, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1198314..1200356, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene uncharacterized protein Neighboring gene 7B2

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

mobile_element

  • Loc: c5374811-5374721 mobile_element_type = transposon:I{}5202

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in eggshell chorion gene amplification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
humpty dumpty
Names
CG2669-PA
CG2669-PB
female sterile(3)272-9
hd-PA
hd-PB
lethal (3) 82Ff
lethal (3) 82Fk

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5372592..5374962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316495.1NP_001303424.1  humpty dumpty, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q540V6, Q9VNA8
    UniProtKB/TrEMBL
    A0A126GUQ3
  2. NM_141274.3NP_649531.1  humpty dumpty, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649531.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q540V6, Q9VNA8
    UniProtKB/TrEMBL
    A0A126GUQ3
    Related
    FBpp0078445