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hk2 hexokinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 406339, updated on 19-Jun-2024

Summary

Official Symbol
hk2provided by ZNC
Official Full Name
hexokinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2017
See related
Ensembl:ENSDARG00000101482 AllianceGenome:ZFIN:ZDB-GENE-040426-2017
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi09d05; fi17h06; zgc:55926; wu:fi09d05; wu:fi17h06; wu:fi31b04
Summary
Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Predicted to be involved in cellular glucose homeostasis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to act upstream of or within carbohydrate metabolic process and phosphorylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; hatching gland; musculature system; and nervous system. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See hk2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (13870340..14004215)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (13370123..13503998)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene adducin 2 (beta) Neighboring gene folliculogenesis specific bHLH transcription factor Neighboring gene neuropeptide FF receptor 1 like 2 Neighboring gene tet methylcytosine dioxygenase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hexokinase-2
Names
DrHXK2
NP_998231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213066.1NP_998231.1  hexokinase-2

    See identical proteins and their annotated locations for NP_998231.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045496
    UniProtKB/TrEMBL
    Q7ZVL7
    Related
    ENSDARP00000136161.1, ENSDART00000160690.3
    Conserved Domains (4) summary
    COG5026
    Location:474911
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    PTZ00107
    Location:12462
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:21219
    Hexokinase_1; Hexokinase
    pfam03727
    Location:675910
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    13870340..14004215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394570.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    40219..183420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)