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chia.2 chitinase, acidic.2 [ Danio rerio (zebrafish) ]

Gene ID: 406338, updated on 2-Nov-2024

Summary

Official Symbol
chia.2provided by ZNC
Official Full Name
chitinase, acidic.2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2014
See related
Ensembl:ENSDARG00000099185 AllianceGenome:ZFIN:ZDB-GENE-040426-2014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
chioIa; zgc:55941; zgc:77889; wu:fb61c11
Summary
Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in extracellular region. Is expressed in gut and liver. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See chia.2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24002518..24007990)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (23764661..23770133)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene contactin 2 Neighboring gene chitinase, acidic.1 Neighboring gene chitinase, acidic.3 Neighboring gene oviductal glycoprotein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
 
enables chitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chitin catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chitinase, acidic.2
Names
chia2
NP_998414.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213249.1NP_998414.1  chitinase, acidic.2 precursor

    See identical proteins and their annotated locations for NP_998414.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065885
    UniProtKB/TrEMBL
    A0A8M1PGM9, Q6P006
    Related
    ENSDARP00000134868.1, ENSDART00000164702.2
    Conserved Domains (3) summary
    cd02872
    Location:23385
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:24363
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:423468
    CBM_14; Chitin binding Peritrophin-A domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    24002518..24007990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)