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sucla2 succinate-CoA ligase ADP-forming subunit beta [ Danio rerio (zebrafish) ]

Gene ID: 406299, updated on 16-Jun-2026
Official Symbol
sucla2provided by ZNC
Official Full Name
succinate-CoA ligase ADP-forming subunit betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1963
See related
Ensembl:ENSDARG00000005359 AllianceGenome:ZFIN:ZDB-GENE-040426-1963
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73397; wu:fb18c11; wu:fj38c11; wu:fj90d07
Summary
Predicted to enable succinate-CoA ligase (ADP-forming) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including axis; hatching gland; mesoderm; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See sucla2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (10996847..11014747)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (10037273..10056640)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene integral membrane protein 2Ba Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b Neighboring gene G protein-coupled receptor 155b Neighboring gene ATPase copper transporting beta

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. NAD+ and Sirt5 restore mitochondrial bioenergetics failure and improve locomotor defects caused by sucla2 mutations. Richard J, et al. JCI Insight, 2026 Jan 23. PMID 41574612, Free PMC Article
  2. SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Gut P, et al. Nat Commun, 2020 Nov 23. PMID 33230181, Free PMC Article
  3. Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish. Xu SS, et al. Zool Res, 2023 Jan 18. PMID 36317480, Free PMC Article
  4. Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. White RJ, et al. Elife, 2022 Feb 17. PMID 35175196, Free PMC Article
  5. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Preferred Names
succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Names
succinate-CoA ligase, ADP-forming, beta subunit
NP_998191.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213026.1 → NP_998191.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

    See identical proteins and their annotated locations for NP_998191.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059701
    UniProtKB/TrEMBL
    A0A8M1PIK4, A0ACM8Q3B3, Q6PBI0
    Related
    ENSDARP00000021652.7, ENSDART00000018503.9
    Conserved Domains (3) summary
    PRK00696
    Location:58 → 448
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:324 → 444
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:58 → 265
    ATP-grasp_2; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    10996847..11014747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_012407279.1 RNA Sequence

  2. XR_012407278.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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