mttp microsomal triglyceride transfer protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mttpprovided by ZNC
Official Full Name: microsomal triglyceride transfer proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040419-2
See related: Ensembl:ENSDARG00000008637 AllianceGenome:ZFIN:ZDB-GENE-040419-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mtp; stl; wu:fd36b01; zgc:111876; zgc:136353
Summary: Enables lipid transfer activity. Involved in lipoprotein transport. Acts upstream of or within several processes, including fatty acid transport; lipoprotein biosynthetic process; and sprouting angiogenesis. Predicted to be active in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in several structures, including gut; liver; marginal blastomere; testis; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2025]
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (12107680..12126648, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (11420880..11440023, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein.
Title: A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein.
In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.
Title: Microsomal triglyceride transfer protein is required for yolk lipid utilization and absorption of dietary lipids in zebrafish larvae.
analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit
Title: Developmental expression and nutritional regulation of a zebrafish gene homologous to mammalian microsomal triglyceride transfer protein large subunit.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables lipid transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphatidylethanolamine transfer activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within digestion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within lipoprotein biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within medium-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: microsomal triglyceride transfer protein large subunit

Names: stalactite

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212970.2 → NP_998135.2 microsomal triglyceride transfer protein large subunit precursor

Status: VALIDATED

Source sequence(s)

BX908747, CABZ01049941, CABZ01050432, CU914777, FO704847

UniProtKB/Swiss-Prot

A0A0R4IVV0, A4IGB9, Q8AXV7

Related

ENSDARP00000024667.9, ENSDART00000015251.9

Conserved Domains (2) summary

pfam09172
Location:703 → 811

DUF1943; Domain of unknown function (DUF1943)

cl26969
Location:26 → 578

Vitellogenin_N; Lipoprotein amino terminal region