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LY6H lymphocyte antigen 6 family member H [ Homo sapiens (human) ]

Gene ID: 4062, updated on 13-Mar-2020

Summary

Official Symbol
LY6Hprovided by HGNC
Official Full Name
lymphocyte antigen 6 family member Hprovided by HGNC
Primary source
HGNC:HGNC:6728
See related
Ensembl:ENSG00000176956 MIM:603625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NMLY6
Expression
Biased expression in brain (RPKM 15.6), stomach (RPKM 1.2) and 1 other tissue See more
Orthologs

Genomic context

See LY6H in Genome Data Viewer
Location:
8q24.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (143157916..143160654, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144239331..144242053, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein FLJ40521-like Neighboring gene ribosomal protein S26 pseudogene 36 Neighboring gene lymphocyte antigen 6 family member L Neighboring gene uncharacterized LOC107986906 Neighboring gene glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lymphocyte antigen 6H
Names
ly-6H
lymphocyte antigen 6 complex, locus H

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130478.2NP_001123950.1  lymphocyte antigen 6H isoform b precursor

    See identical proteins and their annotated locations for NP_001123950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) that is longer at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC083982, AK314139, BC030192
    Consensus CDS
    CCDS47926.1
    UniProtKB/Swiss-Prot
    O94772
    Related
    ENSP00000399485.2, ENST00000414417.6
    Conserved Domains (1) summary
    pfam00021
    Location:49132
    UPAR_LY6; u-PAR/Ly-6 domain
  2. NM_001135655.2NP_001129127.1  lymphocyte antigen 6H isoform b precursor

    See identical proteins and their annotated locations for NP_001129127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) that is longer at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BC030192, DB502453
    Consensus CDS
    CCDS47926.1
    UniProtKB/Swiss-Prot
    O94772
    Related
    ENSP00000342711.4, ENST00000342752.8
    Conserved Domains (1) summary
    pfam00021
    Location:49132
    UPAR_LY6; u-PAR/Ly-6 domain
  3. NM_002347.5NP_002338.3  lymphocyte antigen 6H isoform a precursor

    See identical proteins and their annotated locations for NP_002338.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
    Source sequence(s)
    BC030192, BP347868, DB471677
    Consensus CDS
    CCDS6396.1
    UniProtKB/Swiss-Prot
    O94772
    Related
    ENSP00000409899.2, ENST00000430474.6
    Conserved Domains (1) summary
    pfam00021
    Location:28111
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    143157916..143160654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013413.1XP_016868902.1  lymphocyte antigen 6H isoform X1

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187573.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    153501..156239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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