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Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 406165, updated on 10-Oct-2019

Summary

Official Symbol
Agpat1provided by RGD
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 1provided by RGD
Primary source
RGD:1303287
See related
Ensembl:ENSRNOG00000000437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Kidney (RPKM 171.6), Testes (RPKM 109.8) and 9 other tissues See more
Orthologs

Genomic context

See Agpat1 in Genome Data Viewer
Location:
20p12
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4369399..4378272)
106 current Rn_Celera (GCF_000002265.2) 20 AC_000088.1 (3886956..3894297)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (6448755..6457628)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19 Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene ring finger protein 5 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene FKBP prolyl isomerase like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC94573

Gene Ontology Provided by RGD

Function Evidence Code Pubs
1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Names
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
NP_997623.1
XP_006256034.1
XP_006256036.1
XP_006256037.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212458.1NP_997623.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

    See identical proteins and their annotated locations for NP_997623.1

    Status: VALIDATED

    Source sequence(s)
    BX883044
    UniProtKB/TrEMBL
    Q6MG85
    Related
    ENSRNOP00000000500.4, ENSRNOT00000000500.7
    Conserved Domains (2) summary
    cd07989
    Location:66252
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    COG0204
    Location:41265
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    4369399..4378272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255975.1XP_006256037.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2

    See identical proteins and their annotated locations for XP_006256037.1

    UniProtKB/TrEMBL
    Q6MG85
    Related
    ENSRNOP00000072161.1, ENSRNOT00000088079.1
    Conserved Domains (2) summary
    cd07989
    Location:66252
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    COG0204
    Location:41265
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
  2. XM_006255974.1XP_006256036.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2

    See identical proteins and their annotated locations for XP_006256036.1

    UniProtKB/TrEMBL
    Q6MG85
    Conserved Domains (2) summary
    cd07989
    Location:66252
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    COG0204
    Location:41265
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
  3. XM_006255972.2XP_006256034.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

    Conserved Domains (2) summary
    cd07989
    Location:104290
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    COG0204
    Location:79303
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    3886956..3894297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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