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Notch4 notch receptor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 406162, updated on 19-Apr-2019

Summary

Official Symbol
Notch4provided by RGD
Official Full Name
notch receptor 4provided by RGD
Primary source
RGD:1303282
See related
Ensembl:ENSRNOG00000000442
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Lung (RPKM 59.6), Heart (RPKM 41.6) and 9 other tissues See more
Orthologs

Genomic context

See Notch4 in Genome Data Viewer
Location:
20p12
Exon count:
30
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4329794..4353868)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (6409125..6433141)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene complement C4B (Chido blood group) Neighboring gene serine/threonine kinase 19 pseudogene Neighboring gene serine/threonine kinase 19 Neighboring gene G-protein signaling modulator 3 Neighboring gene PBX homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding ISO
Inferred from Sequence Orthology
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
mammary gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
morphogenesis of a branching structure ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein processing ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
vasculature development ISO
Inferred from Sequence Orthology
more info
PubMed 
venous blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neurogenic locus notch homolog protein 4
Names
notch 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002827.1NP_001002827.1  neurogenic locus notch homolog protein 4 precursor

    See identical proteins and their annotated locations for NP_001002827.1

    Status: PROVISIONAL

    Source sequence(s)
    BX883044
    UniProtKB/TrEMBL
    Q6MG89
    Related
    ENSRNOP00000000513.3, ENSRNOT00000000513.4
    Conserved Domains (8) summary
    cd00054
    Location:429470
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:16251732
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:12451281
    Notch; LNR domain
    pfam06816
    Location:12911337
    NOD; NOTCH protein
    pfam07645
    Location:191224
    EGF_CA; Calcium-binding EGF domain
    pfam07684
    Location:13761415
    NODP; NOTCH protein
    pfam12796
    Location:16301723
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:16261656
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    4329794..4353868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601710.1XP_017457199.1  neurogenic locus notch homolog protein 4 isoform X2

  2. XM_008772740.2XP_008770962.1  neurogenic locus notch homolog protein 4 isoform X1

    Conserved Domains (8) summary
    cd00054
    Location:467508
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:16631770
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:12831319
    Notch; LNR domain
    pfam06816
    Location:13291375
    NOD; NOTCH protein
    pfam07645
    Location:229262
    EGF_CA; Calcium-binding EGF domain
    pfam07684
    Location:14141453
    NODP; NOTCH protein
    pfam12796
    Location:16681761
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:16641694
    ANK; ANK repeat [structural motif]

RNA

  1. XR_001842425.1 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    3846498..3869836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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