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ARNTL aryl hydrocarbon receptor nuclear translocator like [ Homo sapiens (human) ]

Gene ID: 406, updated on 26-Jun-2019

Summary

Official Symbol
ARNTLprovided by HGNC
Official Full Name
aryl hydrocarbon receptor nuclear translocator likeprovided by HGNC
Primary source
HGNC:HGNC:701
See related
Ensembl:ENSG00000133794 MIM:602550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5
Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in adrenal (RPKM 8.3), skin (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See ARNTL in Genome Data Viewer
Location:
11p15.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (13276552..13387268)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (13299325..13408813)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 10 Neighboring gene uncharacterized LOC105376558 Neighboring gene RN7SK pseudogene 151 Neighboring gene BTB domain containing 10 Neighboring gene PTH promoter region Neighboring gene parathyroid hormone

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
NHGRI GWA Catalog
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.
NHGRI GWA Catalog
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of aryl hydrocarbon receptor nuclear translocator-like (ARNTL) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Circadian rhythm, organism-specific biosystem (from KEGG)
    Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Circadian rhythm, conserved biosystem (from KEGG)
    Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Circadian rhythm pathway, organism-specific biosystem (from Pathway Interaction Database)
    Circadian rhythm pathway, organism-specific biosystem
    Circadian rhythm pathway
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
    Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog family of proteins are signaling proteins that are crucial for a number of physiological processes including morphogenesis during development. In adult organisms, it is also involved in ...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
    Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • RORA activates gene expression, organism-specific biosystem (from REACTOME)
    RORA activates gene expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC47515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
bHLH transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm TAS
Traceable Author Statement
more info
 
maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glucocorticoid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidative stress-induced premature senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of skeletal muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of hair cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of type B pancreatic cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
response to redox state IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
chromatoid body ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
aryl hydrocarbon receptor nuclear translocator-like protein 1
Names
ARNT-like protein 1, brain and muscle
PAS domain containing 3
PAS domain-containing protein 3
bHLH-PAS protein JAP3
basic helix-loop-helix family member e5
basic-helix-loop-helix-PAS orphan MOP3
basic-helix-loop-helix-PAS protein MOP3
brain and muscle ARNT-like 1
class E basic helix-loop-helix protein 5
member of PAS protein 3
member of PAS superfamily 3
testis tissue sperm-binding protein Li 50e

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030272.2NP_001025443.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001025443.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (a) is 1 aa shorter compared to isoform c. Variants 1, 2, 10, and 11 all encode isoform a.
    Source sequence(s)
    AK291510, BC041129, BE391243
    Consensus CDS
    CCDS31430.1
    UniProtKB/Swiss-Prot
    O00327
    UniProtKB/TrEMBL
    A0A140VKD3
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:338440
    PAS_3; PAS fold
  2. NM_001030273.2NP_001025444.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_001025444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (b) has a shorter and distinct N-terminus and lacks an alternate internal aa compared to isoform c. Variants 3 and 22 both encode isoform b.
    Source sequence(s)
    AF044288, AK095749, BE391243
    Consensus CDS
    CCDS44543.1
    UniProtKB/Swiss-Prot
    O00327
    Related
    ENSP00000385581.3, ENST00000403510.7
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:295397
    PAS_3; PAS fold
  3. NM_001178.5NP_001169.3  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001169.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (a) is 1 aa shorter compared to isoform c. Variants 1, 2, 10, and 11 all encode isoform a.
    Source sequence(s)
    BC041129, BE391243
    Consensus CDS
    CCDS31430.1
    UniProtKB/Swiss-Prot
    O00327
    UniProtKB/TrEMBL
    A0A140VKD3
    Related
    ENSP00000374357.4, ENST00000389707.8
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:338440
    PAS_3; PAS fold
  4. NM_001297719.1NP_001284648.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001284648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform c. Variants 4, 5, and 9 all encode the same isoform (c).
    Source sequence(s)
    AC016884, AF044288, AK315174, BE391243
    Consensus CDS
    CCDS73259.1
    UniProtKB/Swiss-Prot
    O00327
    UniProtKB/TrEMBL
    B2RCL8
    Related
    ENSP00000384517.1, ENST00000403290.5
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:339441
    PAS_3; PAS fold
  5. NM_001297722.1NP_001284651.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001284651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 4, 5, and 9 all encode the same isoform (c).
    Source sequence(s)
    AF044288, AK291510, BE391243
    Consensus CDS
    CCDS73259.1
    UniProtKB/Swiss-Prot
    O00327
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:339441
    PAS_3; PAS fold
  6. NM_001297724.1NP_001284653.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    See identical proteins and their annotated locations for NP_001284653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate exon compared to variant 4. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform c. Variants 6, 17, 18, 19, 20, and 21 all encode the same isoform (d).
    Source sequence(s)
    BC031214, BE391243
    Consensus CDS
    CCDS76387.1
    UniProtKB/Swiss-Prot
    O00327
    Related
    ENSP00000385915.1, ENST00000401424.5
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  7. NM_001351804.1NP_001338733.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, and 11, encodes isoform a.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS31430.1
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:338440
    PAS_3; PAS fold
  8. NM_001351805.1NP_001338734.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Related
    ENSP00000385897.3, ENST00000403482.7
    Conserved Domains (3) summary
    smart00091
    Location:136195
    PAS; PAS domain
    pfam00010
    Location:61113
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:326428
    PAS_3; PAS fold
  9. NM_001351806.1NP_001338735.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:136195
    PAS; PAS domain
    pfam00010
    Location:61113
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:325427
    PAS_3; PAS fold
  10. NM_001351807.1NP_001338736.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform e.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:339441
    PAS_3; PAS fold
  11. NM_001351808.1NP_001338737.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 6, 18, 19, 20, and 21, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS76387.1
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  12. NM_001351809.1NP_001338738.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform i.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    pfam14598
    Location:322424
    PAS_11; PAS domain
    pfam00010
    Location:57109
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:129236
    PAS; PAS fold
  13. NM_001351810.1NP_001338739.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variant 30, encodes isoform k.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:272323
    PAS_3; PAS fold
  14. NM_001351811.1NP_001338740.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (1) summary
    cl25986
    Location:89191
    PAS_3; PAS fold
  15. NM_001351812.1NP_001338741.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform i.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    pfam14598
    Location:322424
    PAS_11; PAS domain
    pfam00010
    Location:57109
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:129236
    PAS; PAS fold
  16. NM_001351813.1NP_001338742.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:295397
    PAS_3; PAS fold
  17. NM_001351814.1NP_001338743.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform e.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:339441
    PAS_3; PAS fold
  18. NM_001351815.1NP_001338744.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, and 10, encodes isoform a.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS31430.1
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:338440
    PAS_3; PAS fold
  19. NM_001351816.1NP_001338745.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 6, 17, 19, 20, and 21, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS76387.1
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  20. NM_001351817.1NP_001338746.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variant 29, encodes isoform k (also called isoform l).
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:272323
    PAS_3; PAS fold
  21. NM_001351818.1NP_001338747.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS44543.1
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:295397
    PAS_3; PAS fold
  22. NM_001351819.1NP_001338748.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:338440
    PAS_3; PAS fold
  23. NM_001351820.1NP_001338749.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 6, 17, 18, 20 and 21, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS76387.1
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  24. NM_001351821.1NP_001338750.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 6, 17, 18, 19, and 21, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS76387.1
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  25. NM_001351822.1NP_001338751.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 6, 17, 18, 19, and 20, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS76387.1
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  26. NM_001351823.1NP_001338752.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  27. NM_001351824.1NP_001338753.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS73259.1
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:339441
    PAS_3; PAS fold

RNA

  1. NR_147785.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  2. NR_147786.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  3. NR_147787.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  4. NR_147788.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  5. NR_147789.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  6. NR_147790.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  7. NR_147791.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    13276552..13387268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017739.2XP_016873228.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3

  2. XM_017017738.2XP_016873227.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

  3. XM_011520105.3XP_011518407.2  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X2

  4. XM_011520107.3XP_011518409.2  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X4

  5. XM_017017744.1XP_016873233.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X9

    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:295397
    PAS_3; PAS fold
  6. XM_006718234.1XP_006718297.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X8

    See identical proteins and their annotated locations for XP_006718297.1

    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  7. XM_011520111.1XP_011518413.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011518413.1

    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:296398
    PAS_3; PAS fold
  8. XM_011520109.1XP_011518411.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011518411.1

    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:339441
    PAS_3; PAS fold
  9. XM_017017741.1XP_016873230.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X6

    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:338440
    PAS_3; PAS fold
  10. XM_017017748.1XP_016873237.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X10

    UniProtKB/Swiss-Prot
    O00327
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    pfam00010
    Location:3183
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:295397
    PAS_3; PAS fold
  11. XM_024448522.1XP_024304290.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X7

    Conserved Domains (3) summary
    pfam14598
    Location:322424
    PAS_11; PAS domain
    pfam00010
    Location:57109
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:129236
    PAS; PAS fold

RNA

  1. XR_002957147.1 RNA Sequence

  2. XR_001747876.2 RNA Sequence

  3. XR_002957148.1 RNA Sequence

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