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ARNTL aryl hydrocarbon receptor nuclear translocator like [ Homo sapiens (human) ]

Gene ID: 406, updated on 25-Nov-2021

Summary

Official Symbol
ARNTLprovided by HGNC
Official Full Name
aryl hydrocarbon receptor nuclear translocator likeprovided by HGNC
Primary source
HGNC:HGNC:701
See related
Ensembl:ENSG00000133794 MIM:602550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5
Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in adrenal (RPKM 8.3), skin (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See ARNTL in Genome Data Viewer
Location:
11p15.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (13276552..13387268)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (13298199..13408813)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 10 Neighboring gene uncharacterized LOC105376558 Neighboring gene RN7SK pseudogene 151 Neighboring gene BTB domain containing 10 Neighboring gene PTH promoter region Neighboring gene parathyroid hormone

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
GeneReviews: Not available
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.
GeneReviews: Not available
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
GeneReviews: Not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of aryl hydrocarbon receptor nuclear translocator-like (ARNTL) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC47515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of glucocorticoid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oxidative stress-induced premature senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of skeletal muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of hair cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of type B pancreatic cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to redox state IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of CLOCK-BMAL transcription complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
part_of aryl hydrocarbon receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in chromatoid body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
aryl hydrocarbon receptor nuclear translocator-like protein 1
Names
ARNT-like protein 1, brain and muscle
PAS domain containing 3
PAS domain-containing protein 3
bHLH-PAS protein JAP3
basic helix-loop-helix family member e5
basic-helix-loop-helix-PAS orphan MOP3
basic-helix-loop-helix-PAS protein MOP3
brain and muscle ARNT-like 1
class E basic helix-loop-helix protein 5
member of PAS protein 3
member of PAS superfamily 3
testis tissue sperm-binding protein Li 50e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030272.3NP_001025443.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001025443.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (a) is 1 aa shorter compared to isoform c. Variants 1, 2, 10, and 11 all encode isoform a.
    Source sequence(s)
    AK291510, BC041129, BE391243
    UniProtKB/Swiss-Prot
    O00327
    UniProtKB/TrEMBL
    A0A140VKD3
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:338440
    PAS_11; PAS domain
  2. NM_001030273.3NP_001025444.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_001025444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (b) has a shorter and distinct N-terminus and lacks an alternate internal aa compared to isoform c. Variants 3 and 22 both encode isoform b.
    Source sequence(s)
    AF044288, AK095749, BE391243
    Consensus CDS
    CCDS44543.1
    UniProtKB/Swiss-Prot
    O00327
    Related
    ENSP00000385915.2, ENST00000401424.6
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:295397
    PAS_11; PAS domain
  3. NM_001178.6NP_001169.3  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001169.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (a) is 1 aa shorter compared to isoform c. Variants 1, 2, 10, and 11 all encode isoform a.
    Source sequence(s)
    BC041129, BE391243
    UniProtKB/Swiss-Prot
    O00327
    UniProtKB/TrEMBL
    A0A140VKD3
    Related
    ENSP00000374357.4, ENST00000389707.8
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:338440
    PAS_11; PAS domain
  4. NM_001297719.2NP_001284648.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001284648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform c. Variants 4, 5, and 9 all encode the same isoform (c).
    Source sequence(s)
    AC016884, AF044288, AK315174, BE391243
    Consensus CDS
    CCDS73259.1
    UniProtKB/Swiss-Prot
    O00327
    UniProtKB/TrEMBL
    B2RCL8
    Related
    ENSP00000384517.1, ENST00000403290.6
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:339441
    PAS_11; PAS domain
  5. NM_001297722.2NP_001284651.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001284651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 4, 5, and 9 all encode the same isoform (c).
    Source sequence(s)
    AF044288, AK291510, BE391243
    Consensus CDS
    CCDS73259.1
    UniProtKB/Swiss-Prot
    O00327
    Related
    ENSP00000385581.4, ENST00000403510.8
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:339441
    PAS_11; PAS domain
  6. NM_001297724.2NP_001284653.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    See identical proteins and their annotated locations for NP_001284653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate exon compared to variant 4. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform c. Variants 6, 17, 18, 19, 20, and 21 all encode the same isoform (d).
    Source sequence(s)
    BC031214, BE391243
    UniProtKB/Swiss-Prot
    O00327
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  7. NM_001351804.1NP_001338733.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, and 11, encodes isoform a.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:338440
    PAS_11; PAS domain
  8. NM_001351805.2NP_001338734.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Related
    ENSP00000385897.3, ENST00000403482.7
    Conserved Domains (3) summary
    smart00091
    Location:136195
    PAS; PAS domain
    pfam00010
    Location:61113
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:326428
    PAS_3; PAS fold
  9. NM_001351806.2NP_001338735.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:136195
    PAS; PAS domain
    pfam00010
    Location:61113
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:325427
    PAS_3; PAS fold
  10. NM_001351807.2NP_001338736.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform e.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:339441
    PAS_11; PAS domain
  11. NM_001351808.2NP_001338737.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 6, 18, 19, 20, and 21, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  12. NM_001351809.2NP_001338738.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform i.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:132191
    PAS; PAS domain
    cd11438
    Location:50113
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:322424
    PAS_11; PAS domain
  13. NM_001351810.2NP_001338739.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variant 30, encodes isoform k.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:272323
    PAS_3; PAS fold
  14. NM_001351811.2NP_001338740.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (1) summary
    pfam14598
    Location:89191
    PAS_11; PAS domain
  15. NM_001351812.2NP_001338741.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform i.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:132191
    PAS; PAS domain
    cd11438
    Location:50113
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:322424
    PAS_11; PAS domain
  16. NM_001351813.2NP_001338742.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:295397
    PAS_11; PAS domain
  17. NM_001351814.2NP_001338743.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform e.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:339441
    PAS_11; PAS domain
  18. NM_001351815.2NP_001338744.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, and 10, encodes isoform a.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:338440
    PAS_11; PAS domain
  19. NM_001351816.2NP_001338745.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 6, 17, 19, 20, and 21, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  20. NM_001351817.2NP_001338746.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variant 29, encodes isoform k (also called isoform l).
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    pfam00010
    Location:74126
    HLH; Helix-loop-helix DNA-binding domain
    cl25986
    Location:272323
    PAS_3; PAS fold
  21. NM_001351818.2NP_001338747.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS44543.1
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:295397
    PAS_11; PAS domain
  22. NM_001351819.2NP_001338748.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Related
    ENSP00000501212.1, ENST00000673817.1
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:338440
    PAS_11; PAS domain
  23. NM_001351820.2NP_001338749.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 6, 17, 18, 20 and 21, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  24. NM_001351821.2NP_001338750.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 6, 17, 18, 19, and 21, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  25. NM_001351822.2NP_001338751.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 6, 17, 18, 19, and 20, encodes isoform d.
    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  26. NM_001351823.2NP_001338752.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  27. NM_001351824.2NP_001338753.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AC016884, AC022878
    Consensus CDS
    CCDS73259.1
    Related
    ENSP00000433571.2, ENST00000529388.6
    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:339441
    PAS_11; PAS domain

RNA

  1. NR_147785.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  2. NR_147786.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  3. NR_147787.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  4. NR_147788.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  5. NR_147789.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
  6. NR_147790.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Related
    ENST00000673626.1
  7. NR_147791.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016884, AC022878
    Related
    ENST00000673892.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    13276552..13387268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017739.2XP_016873228.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3

  2. XM_017017738.2XP_016873227.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1

  3. XM_011520105.3XP_011518407.2  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X2

  4. XM_011520107.3XP_011518409.2  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X4

  5. XM_017017744.1XP_016873233.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X9

    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:295397
    PAS_11; PAS domain
  6. XM_006718234.1XP_006718297.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X8

    See identical proteins and their annotated locations for XP_006718297.1

    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  7. XM_011520111.1XP_011518413.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011518413.1

    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:296398
    PAS_11; PAS domain
  8. XM_011520109.1XP_011518411.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011518411.1

    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:339441
    PAS_11; PAS domain
  9. XM_017017741.1XP_016873230.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X6

    Conserved Domains (3) summary
    smart00091
    Location:149208
    PAS; PAS domain
    cd11438
    Location:67130
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:338440
    PAS_11; PAS domain
  10. XM_017017748.1XP_016873237.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X10

    UniProtKB/Swiss-Prot
    O00327
    Conserved Domains (3) summary
    smart00091
    Location:106165
    PAS; PAS domain
    cd11438
    Location:2487
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:295397
    PAS_11; PAS domain
  11. XM_024448522.1XP_024304290.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X7

    Conserved Domains (3) summary
    smart00091
    Location:132191
    PAS; PAS domain
    cd11438
    Location:50113
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam14598
    Location:322424
    PAS_11; PAS domain

RNA

  1. XR_002957147.1 RNA Sequence

  2. XR_001747876.2 RNA Sequence

  3. XR_002957148.1 RNA Sequence

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