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esrrga estrogen-related receptor gamma a [ Danio rerio (zebrafish) ]

Gene ID: 405890, updated on 9-Sep-2025
Official Symbol
esrrgaprovided by ZNC
Official Full Name
estrogen-related receptor gamma aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030821-2
See related
Ensembl:ENSDARG00000004861 AllianceGenome:ZFIN:ZDB-GENE-030821-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
errg; esrrg; errgamma
Summary
Enables DNA-binding transcription factor activity. Acts upstream of or within DNA-templated transcription and otic vesicle development. Predicted to be active in chromatin and nucleus. Is expressed in basal plate midbrain region; nervous system; pronephric duct; and tail bud. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See esrrga in Genome Data Viewer
Location:
chromosome: 17
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 17 NC_133192.1 (31244246..31499589, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 17 NC_007128.7 (29794802..30054077, complement)

Chromosome 17 - NC_133192.1Genomic Context describing neighboring genes Neighboring gene Usher syndrome 2A (autosomal recessive, mild) Neighboring gene uncharacterized LOC137488110 Neighboring gene uncharacterized LOC141378602 Neighboring gene uncharacterized LOC103910029 Neighboring gene spermatogenesis associated 17

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Estrogen-related receptor γ is an in vivo receptor of bisphenol A. Tohmé M, et al. FASEB J, 2014 Jul. PMID 24744145
  2. Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (Danio rerio) Embryo Test and Molecular Docking. Makarova K, et al. Zebrafish, 2016 Oct. PMID 27486708
  3. Targeted transgene integration overcomes variability of position effects in zebrafish. Roberts JA, et al. Development, 2014 Feb. PMID 24449846, Free PMC Article
  4. Cloning and developmental expression of five estrogen-receptor related genes in the zebrafish. Bardet PL, et al. Dev Genes Evol, 2004 May. PMID 15088146
  5. Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transition. Bardet PL, et al. Evol Dev, 2005 May-Jun. PMID 15876195

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hormone binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within otic vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of macromolecule biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to lipid IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
estrogen-related receptor gamma a
Names
NR3B3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212954.1 → NP_998119.1  estrogen-related receptor gamma a

    See identical proteins and their annotated locations for NP_998119.1

    Status: PROVISIONAL

    Source sequence(s)
    AY556397
    UniProtKB/TrEMBL
    A0A0G2KVP5, A0A8N1Z284, Q6Q6F4
    Related
    ENSDARP00000136509.2, ENSDART00000166976.2
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133192.1 Reference GRCz12tu Primary Assembly

    Range
    31244246..31499589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073927129.1 → XP_073783230.1  estrogen-related receptor gamma a isoform X8

    UniProtKB/TrEMBL
    A0A0G2KVP5, A0A8N1Z284, Q6Q6F4

  2. XM_068214375.2 → XP_068070476.1  estrogen-related receptor gamma a isoform X7

    UniProtKB/TrEMBL
    A0AB32T3L3

  3. XM_073927116.1 → XP_073783217.1  estrogen-related receptor gamma a isoform X4

  4. XM_073927134.1 → XP_073783235.1  estrogen-related receptor gamma a isoform X8

    UniProtKB/TrEMBL
    A0A0G2KVP5, A0A8N1Z284, Q6Q6F4

  5. XM_073927126.1 → XP_073783227.1  estrogen-related receptor gamma a isoform X7

    UniProtKB/TrEMBL
    A0AB32T3L3

  6. XM_073927121.1 → XP_073783222.1  estrogen-related receptor gamma a isoform X4

  7. XM_073927131.1 → XP_073783232.1  estrogen-related receptor gamma a isoform X8

    UniProtKB/TrEMBL
    A0A0G2KVP5, A0A8N1Z284, Q6Q6F4

  8. XM_073927124.1 → XP_073783225.1  estrogen-related receptor gamma a isoform X7

    UniProtKB/TrEMBL
    A0AB32T3L3

  9. XM_073927119.1 → XP_073783220.1  estrogen-related receptor gamma a isoform X4

  10. XM_073927110.1 → XP_073783211.1  estrogen-related receptor gamma a isoform X3

    UniProtKB/TrEMBL
    A0AB32TAN4

  11. XM_073927114.1 → XP_073783215.1  estrogen-related receptor gamma a isoform X3

    UniProtKB/TrEMBL
    A0AB32TAN4

  12. XM_073927132.1 → XP_073783233.1  estrogen-related receptor gamma a isoform X8

    UniProtKB/TrEMBL
    A0A0G2KVP5, A0A8N1Z284, Q6Q6F4

  13. XM_073927125.1 → XP_073783226.1  estrogen-related receptor gamma a isoform X7

    UniProtKB/TrEMBL
    A0AB32T3L3

  14. XM_073927120.1 → XP_073783221.1  estrogen-related receptor gamma a isoform X4

  15. XM_073927112.1 → XP_073783213.1  estrogen-related receptor gamma a isoform X3

    UniProtKB/TrEMBL
    A0AB32TAN4

  16. XM_073927115.1 → XP_073783216.1  estrogen-related receptor gamma a isoform X3

    UniProtKB/TrEMBL
    A0AB32TAN4

  17. XM_068214373.2 → XP_068070474.1  estrogen-related receptor gamma a isoform X3

    UniProtKB/TrEMBL
    A0AB32TAN4

  18. XM_073927130.1 → XP_073783231.1  estrogen-related receptor gamma a isoform X8

    UniProtKB/TrEMBL
    A0A0G2KVP5, A0A8N1Z284, Q6Q6F4

  19. XM_068214376.2 → XP_068070477.1  estrogen-related receptor gamma a isoform X7

    UniProtKB/TrEMBL
    A0AB32T3L3

  20. XM_073927118.1 → XP_073783219.1  estrogen-related receptor gamma a isoform X4

  21. XM_073927113.1 → XP_073783214.1  estrogen-related receptor gamma a isoform X3

    UniProtKB/TrEMBL
    A0AB32TAN4

  22. XM_073927127.1 → XP_073783228.1  estrogen-related receptor gamma a isoform X7

    UniProtKB/TrEMBL
    A0AB32T3L3

  23. XM_073927122.1 → XP_073783223.1  estrogen-related receptor gamma a isoform X4

  24. XM_073927135.1 → XP_073783236.1  estrogen-related receptor gamma a isoform X8

    UniProtKB/TrEMBL
    A0A0G2KVP5, A0A8N1Z284, Q6Q6F4

  25. XM_073927123.1 → XP_073783224.1  estrogen-related receptor gamma a isoform X6

  26. XM_068214374.2 → XP_068070475.1  estrogen-related receptor gamma a isoform X5

    UniProtKB/TrEMBL
    A0AB32TAJ7

  27. XM_009293126.5 → XP_009291401.1  estrogen-related receptor gamma a isoform X2

    UniProtKB/TrEMBL
    A0A8M3B2H9, F6PD98
    Related
    ENSDARP00000005364.5
    Conserved Domains (2) summary
    cd06946
    Location:280 → 499
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:165 → 261
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  28. XM_005158771.6 → XP_005158828.1  estrogen-related receptor gamma a isoform X1

    UniProtKB/TrEMBL
    A0A8M2B590
    Conserved Domains (2) summary
    cd06946
    Location:287 → 506
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:165 → 261
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  29. XM_073927133.1 → XP_073783234.1  estrogen-related receptor gamma a isoform X8

    UniProtKB/TrEMBL
    A0A0G2KVP5, A0A8N1Z284, Q6Q6F4

  30. XM_068214377.2 → XP_068070478.1  estrogen-related receptor gamma a isoform X7

    UniProtKB/TrEMBL
    A0AB32T3L3

  31. XM_073927117.1 → XP_073783218.1  estrogen-related receptor gamma a isoform X4

  32. XM_068214371.2 → XP_068070472.1  estrogen-related receptor gamma a isoform X3

    UniProtKB/TrEMBL
    A0AB32TAN4
Nucleotide Protein Strain
Heading Accession and Version

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