eIF3f1 eukaryotic translation initiation factor 3 subunit f1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF3f1provided by FlyBase
Official Full Name: eukaryotic translation initiation factor 3 subunit f1provided by FlyBase
Primary source: FLYBASE:FBgn0037270
Locus tag: Dmel_CG9769
See related: AllianceGenome:FB:FBgn0037270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9769; Dmel\CG9769; eIF3-S5; eif3f; eIF3f; Q9VN50
Summary: Enables metal-dependent deubiquitinase activity. Involved in defense response to bacterium and positive regulation of signal transduction. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 67. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4712882..4714182, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (538604..539904, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila eIF3f1 mediates host immune defense by targeting dTak1.
Title: Drosophila eIF3f1 mediates host immune defense by targeting dTak1.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal-dependent deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal-dependent deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IBA Inferred from Biological aspect of Ancestor more info

NP_649489.1

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