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rpk ripped pocket [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40580, updated on 11-Apr-2024

Summary

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Official Symbol
rpkprovided by FlyBase
Official Full Name
ripped pocketprovided by FlyBase
Primary source
FLYBASE:FBgn0022981
Locus tag
Dmel_CG1058
See related
AllianceGenome:FB:FBgn0022981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1058; dGNaC1; Dmel\CG1058; GNaC1; ppk2; Rpk; RPK
Summary
Predicted to enable sodium channel activity. Involved in detection of mechanical stimulus involved in sensory perception of pain and sensory perception of touch. Located in axon; dendrite; and neuronal cell body. Is expressed in reproductive system and wing disc. Orthologous to human ASIC5 (acid sensing ion channel subunit family member 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rpk in Genome Data Viewer
Location:
82C5-82C5; 3-47.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4645981..4648884)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (471703..474606)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 31 Neighboring gene nuclease slx1 Neighboring gene Dorsal interacting protein 2 Neighboring gene antisense RNA:CR44155 Neighboring gene Karyopherin beta 3 Neighboring gene spartin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dGNaC1, a gonad-specific amiloride-sensitive Na+ channel. Darboux I, et al. J Biol Chem, 1998 Apr 17. PMID 9545267
  2. Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. Hunter GL, et al. Development, 2014 Jan. PMID 24306105, Free PMC Article
  3. DEG/ENaC channels: a touchy superfamily that watches its salt. Mano I, et al. Bioessays, 1999 Jul. PMID 10472184
  4. Amiloride-sensitive Na channels. Horisberger JD. Curr Opin Cell Biol, 1998 Aug. PMID 9719863
  5. H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels. Waldmann R, et al. Curr Opin Neurobiol, 1998 Jun. PMID 9687356

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in detection of mechanical stimulus involved in sensory perception of pain IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ripped pocket
Names
CG1058-PA
CG1058-PB
gonad-specific amiloride-sensitive sodium channel 1
ripped-pocket
rpk-PA
rpk-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4645981..4648884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259980.2 → NP_001246909.1  ripped pocket, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246909.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K691, B5RJJ1
    Conserved Domains (1) summary
    pfam00858
    Location:39 → 552
    ASC; Amiloride-sensitive sodium channel

  2. NM_079501.4 → NP_524225.1  ripped pocket, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524225.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJJ1, O46342, Q9VN43
    Related
    FBpp0078499
    Conserved Domains (1) summary
    pfam00858
    Location:39 → 546
    ASC; Amiloride-sensitive sodium channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K691 A0A0B4K691
O46342 O46342
Q8T0E5 Q8T0E5

Gene LinkOut

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