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LTK leukocyte receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 4058, updated on 18-Aug-2020

Summary

Official Symbol
LTKprovided by HGNC
Official Full Name
leukocyte receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:6721
See related
Ensembl:ENSG00000062524 MIM:151520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TYK1
Summary
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Expression
Broad expression in duodenum (RPKM 6.4), lung (RPKM 6.1) and 15 other tissues See more
Orthologs

Genomic context

See LTK in Genome Data Viewer
Location:
15q15.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41503637..41513887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41795840..41806085, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6351 Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene RNA polymerase II associated protein 1 Neighboring gene elongin C pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leukocyte tyrosine kinase receptor
Names
protein tyrosine kinase 1
NP_001129157.1
NP_002335.2
NP_996844.1
XP_011519858.1
XP_011519859.1
XP_016877670.1
XP_016877671.1
XP_016877672.1
XP_024305686.1
XP_024305687.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135685.2NP_001129157.1  leukocyte tyrosine kinase receptor isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two internal coding exons and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (3) is missing two internal segments and has a short segment in an alternate reading frame but with the same N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC016134, AC087721, AK296892, CA394397
    Consensus CDS
    CCDS45237.1
    UniProtKB/Swiss-Prot
    P29376
    Related
    ENSP00000392196.2, ENST00000453182.2
    Conserved Domains (2) summary
    pfam07714
    Location:415647
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:414649
    PKc_like; Protein Kinases, catalytic domain
  2. NM_002344.6NP_002335.2  leukocyte tyrosine kinase receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_002335.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC087721, AK296892, CA394397, D16105
    Consensus CDS
    CCDS10077.1
    UniProtKB/Swiss-Prot
    P29376
    Related
    ENSP00000263800.6, ENST00000263800.11
    Conserved Domains (2) summary
    cd05036
    Location:503779
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam07714
    Location:510777
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_206961.4NP_996844.1  leukocyte tyrosine kinase receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_996844.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is lacking one of the internal coding exons compared to variant 1. This results in an isoform (2) that is missing a 61 aa segment compared to isoform 1.
    Source sequence(s)
    AC016134, AC087721, CA394397, X60702
    Consensus CDS
    CCDS10078.1
    UniProtKB/Swiss-Prot
    P29376
    Related
    ENSP00000347293.5, ENST00000355166.9
    Conserved Domains (2) summary
    cd05036
    Location:442718
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam07714
    Location:449716
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41503637..41513887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022181.1XP_016877670.1  leukocyte tyrosine kinase receptor isoform X1

  2. XM_011521557.2XP_011519859.1  leukocyte tyrosine kinase receptor isoform X6

    Conserved Domains (2) summary
    cd05036
    Location:463739
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam07714
    Location:470737
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_011521556.2XP_011519858.1  leukocyte tyrosine kinase receptor isoform X2

    Conserved Domains (2) summary
    cd05036
    Location:519795
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam07714
    Location:526793
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_017022182.1XP_016877671.1  leukocyte tyrosine kinase receptor isoform X4

  5. XM_017022183.1XP_016877672.1  leukocyte tyrosine kinase receptor isoform X7

  6. XM_024449918.1XP_024305686.1  leukocyte tyrosine kinase receptor isoform X3

    Conserved Domains (1) summary
    cd05036
    Location:508784
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
  7. XM_024449919.1XP_024305687.1  leukocyte tyrosine kinase receptor isoform X5

    Conserved Domains (1) summary
    cd05036
    Location:464740
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

RNA

  1. XR_001751277.1 RNA Sequence

  2. XR_001751279.1 RNA Sequence

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