il1b interleukin 1, beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: il1bprovided by ZNC
Official Full Name: interleukin 1, betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040702-2
See related: Ensembl:ENSDARG00000098700 AllianceGenome:ZFIN:ZDB-GENE-040702-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: il1-b; zgc:111873
Summary: Predicted to enable cytokine activity. Acts upstream of or within several processes, including fin regeneration; leukocyte chemotaxis; and response to bacterium. Predicted to be located in cytosol; extracellular region; and lysosome. Predicted to be active in extracellular space. Is expressed in several structures, including bone tissue; digestive system; heart; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); cervix disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	10	NC_133185.1 (50055911..50071059)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (44955378..44963775)

Chromosome 10 - NC_133185.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury.
Title: CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury.
Macrophage-Derived IL-1beta Regulates Emergency Myelopoiesis via the NF-kappaB and C/ebpbeta in Zebrafish.
Title: Macrophage-Derived IL-1β Regulates Emergency Myelopoiesis via the NF-κB and C/ebpβ in Zebrafish.
Immune genes, IL1beta and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads.
Title: Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads.
Macrophage-less irf8 mutants show prolonged inflammation with elevated levels of Tnf-alpha and Il-1beta.
Title: Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.
This study reveals that proper levels of Il1b signaling and tissue inflammation, which are tuned by macrophages, play a crucial role in tissue regeneration.
Title: Transient inflammatory response mediated by interleukin-1β is required for proper regeneration in zebrafish fin fold.
Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase dependent manner.
Title: Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.
Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.
Title: Systemic response to ultraviolet radiation involves induction of leukocytic IL-1β and inflammation in zebrafish.
findings reveal that the Il-1beta-Myd88 axis and NADPH oxidase-mediated ROS signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.
Title: IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model.
the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae
Title: High cholesterol diet induces IL-1β expression in adult but not larval zebrafish.
These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.
Title: Roles of inflammatory caspases during processing of zebrafish interleukin-1β in Francisella noatunensis infection.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fever generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-1 beta

Names: interlukin-1 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212844.2 → NP_998009.2 interleukin-1 beta

Status: VALIDATED

Source sequence(s)

AM941672

UniProtKB/TrEMBL

A0A8M1PI54, E6N152

Related

ENSDARP00000140751.1, ENSDART00000169225.2

Conserved Domains (1) summary

cl00094
Location:129 → 279

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).