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syk spleen tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 405769, updated on 22-Nov-2020

Summary

Official Symbol
sykprovided by ZNC
Official Full Name
spleen tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040702-3
See related
Ensembl:ENSDARG00000008186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Orthologs

Genomic context

See syk in Genome Data Viewer
Location:
chromosome: 10
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5533840..5591965, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5533536..5591675, complement)
103 previous assembly Zv9 (GCF_000002035.4) 10 NC_007121.5 (5538284..5595322, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene nuclear factor, interleukin 3 regulated Neighboring gene AU RNA binding protein/enoyl-CoA hydratase Neighboring gene DIRAS family GTPase 2 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lymphangiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of alpha-beta T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mast cell degranulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase SYK
Names
spleen protein tyrosine kinase
NP_998008.2
XP_005155595.1
XP_005155596.1
XP_021334822.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212843.2NP_998008.2  tyrosine-protein kinase SYK

    Status: VALIDATED

    Source sequence(s)
    CD284981, CU466285, FP102769
    UniProtKB/TrEMBL
    A0A0R4IBB3
    Related
    ENSDARP00000122788.4, ENSDART00000141943.4
    Conserved Domains (3) summary
    cd05116
    Location:325581
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:8111
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:159260
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    5533840..5591965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155539.4XP_005155596.1  tyrosine-protein kinase SYK isoform X1

    See identical proteins and their annotated locations for XP_005155596.1

    UniProtKB/TrEMBL
    F1QFN4
    Conserved Domains (4) summary
    cd05116
    Location:348604
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:8111
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:159260
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    pfam07714
    Location:349599
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_021479147.1XP_021334822.1  tyrosine-protein kinase SYK isoform X2

    Related
    ENSDARP00000132135.1, ENSDART00000164558.2
    Conserved Domains (3) summary
    cd05116
    Location:325581
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:8111
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:159260
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
  3. XM_005155538.4XP_005155595.1  tyrosine-protein kinase SYK isoform X1

    See identical proteins and their annotated locations for XP_005155595.1

    UniProtKB/TrEMBL
    F1QFN4
    Related
    ENSDARP00000003321.7, ENSDART00000005292.8
    Conserved Domains (4) summary
    cd05116
    Location:348604
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:8111
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:159260
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    pfam07714
    Location:349599
    Pkinase_Tyr; Protein tyrosine kinase
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