blnk B cell linker [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: blnkprovided by ZNC
Official Full Name: B cell linkerprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040702-4
See related: Ensembl:ENSDARG00000042722 AllianceGenome:ZFIN:ZDB-GENE-040702-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway and intracellular signal transduction. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 4. Orthologous to human BLNK (B cell linker). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	13	NC_133188.1 (54324607..54391372, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (50520563..50567658, complement)

Chromosome 13 - NC_133188.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: B-cell linker protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212838.1 → NP_998003.1 B-cell linker protein

See identical proteins and their annotated locations for NP_998003.1

Status: PROVISIONAL

Source sequence(s)

AF388205

UniProtKB/TrEMBL

A0A8M6Z948, Q8JI35

Related

ENSDARP00000062683.5, ENSDART00000062684.7

Conserved Domains (1) summary

cd09929
Location:369 → 489

SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)