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CYP4F3 cytochrome P450 family 4 subfamily F member 3 [ Homo sapiens (human) ]

Gene ID: 4051, updated on 21-Dec-2019

Summary

Official Symbol
CYP4F3provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 3provided by HGNC
Primary source
HGNC:HGNC:2646
See related
Ensembl:ENSG00000186529 MIM:601270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPF3; CYP4F; LTB4H; CYPIVF3
Summary
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019]
Expression
Biased expression in liver (RPKM 51.6), bone marrow (RPKM 29.9) and 6 other tissues See more
Orthologs

Genomic context

See CYP4F3 in Genome Data Viewer
Location:
19p13.12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15640897..15662825)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15751701..15771570)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene 2 Neighboring gene cytochrome P450 family 4 subfamily F member 8 Neighboring gene cytochrome P450 family 4 subfamily F member 10, pseudogene Neighboring gene cytochrome P450 family 4 subfamily F member 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
leukotriene-B4 20-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
icosanoid metabolic process TAS
Traceable Author Statement
more info
 
leukotriene B4 catabolic process IEA
Inferred from Electronic Annotation
more info
 
leukotriene metabolic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 4F3
Names
20-HETE synthase
20-hydroxyeicosatetraenoic acid synthase
cytochrome P-450
cytochrome P450, family 4, subfamily F, polypeptide 3
cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase)
cytochrome P450-LTB-omega
docosahexaenoic acid omega-hydroxylase CYP4F3
leukotriene B4 omega hydroxylase
leukotriene-B(4) 20-monooxygenase 2
leukotriene-B(4) omega-hydroxylase 2
leukotriene-B4 20-monooxygenase
NP_000887.2
NP_001186137.1
NP_001186138.1
NP_001356625.1
XP_005259968.1
XP_011526316.1
XP_016882304.1
XP_024307283.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007964.1 RefSeqGene

    Range
    5001..24864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000896.3NP_000887.2  cytochrome P450 4F3 isoform a

    See identical proteins and their annotated locations for NP_000887.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a, which is the same length but has internal differences compared to isoform b.
    Source sequence(s)
    AB002454, AD000685, D12621
    Consensus CDS
    CCDS12332.1
    UniProtKB/Swiss-Prot
    Q08477
    UniProtKB/TrEMBL
    A0A024R7J8
    Related
    ENSP00000221307.6, ENST00000221307.13
    Conserved Domains (1) summary
    pfam00067
    Location:52515
    p450; Cytochrome P450
  2. NM_001199208.2NP_001186137.1  cytochrome P450 4F3 isoform b

    See identical proteins and their annotated locations for NP_001186137.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 1. The resulting isoform (b) is the same length but has a different internal segment compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AB002454, AD000685, BC136299, DB184202
    Consensus CDS
    CCDS59362.1
    UniProtKB/Swiss-Prot
    Q08477
    UniProtKB/TrEMBL
    A0A024R7I2
    Related
    ENSP00000466988.1, ENST00000591058.5
    Conserved Domains (1) summary
    pfam00067
    Location:52515
    p450; Cytochrome P450
  3. NM_001199209.2NP_001186138.1  cytochrome P450 4F3 isoform b

    See identical proteins and their annotated locations for NP_001186138.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon, and contains another alternate in-frame exon compared to variant 1. The resulting isoform (b) is the same length but has a different internal segment compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AD000685, AK316136, BC136299, DB184202
    Consensus CDS
    CCDS59362.1
    UniProtKB/Swiss-Prot
    Q08477
    UniProtKB/TrEMBL
    A0A024R7I2
    Related
    ENSP00000466395.1, ENST00000586182.6
    Conserved Domains (1) summary
    pfam00067
    Location:52515
    p450; Cytochrome P450
  4. NM_001369696.1NP_001356625.1  cytochrome P450 4F3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AD000685
    Related
    ENSP00000468105.1, ENST00000585846.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15640897..15662825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451515.1XP_024307283.1  cytochrome P450 4F3 isoform X2

    Conserved Domains (1) summary
    cl12078
    Location:52306
    p450; Cytochrome P450
  2. XM_017026815.1XP_016882304.1  cytochrome P450 4F3 isoform X1

  3. XM_005259911.5XP_005259968.1  cytochrome P450 4F3 isoform X3

    See identical proteins and their annotated locations for XP_005259968.1

    Conserved Domains (1) summary
    pfam00067
    Location:1366
    p450; Cytochrome P450
  4. XM_011528014.3XP_011526316.1  cytochrome P450 4F3 isoform X3

    See identical proteins and their annotated locations for XP_011526316.1

    Conserved Domains (1) summary
    pfam00067
    Location:1366
    p450; Cytochrome P450
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