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ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens (human) ]

Gene ID: 405, updated on 7-Jul-2024

Summary

Official Symbol
ARNTprovided by HGNC
Official Full Name
aryl hydrocarbon receptor nuclear translocatorprovided by HGNC
Primary source
HGNC:HGNC:700
See related
Ensembl:ENSG00000143437 MIM:126110; AllianceGenome:HGNC:700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARNT1; HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
Summary
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression
Ubiquitous expression in ovary (RPKM 16.9), placenta (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

See ARNT in Genome Data Viewer
Location:
1q21.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150809713..150876599, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149933391..150000287, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150782189..150849075, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene short coiled-coil protein pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150753350-150754207 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:150754208-150755064 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150766964 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150774101 Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 3 Neighboring gene cathepsin K Neighboring gene RNA, U6 small nuclear 1309, pseudogene Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150800090 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150800655 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150808889 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150818234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150822359-150823012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150823013-150823665 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150825511 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150826831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150846639-150847140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150847141-150847640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1306 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:150849134-150849407 Neighboring gene uncharacterized LOC107985204 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150856806 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150858571 Neighboring gene RPS27A pseudogene 6 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150864113 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150864992 Neighboring gene cortexin domain containing 2 Neighboring gene CYCS pseudogene 51

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.
EBI GWAS Catalog
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA downregulates ARNT gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 
involved_in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation IC
Inferred by Curator
more info
 
involved_in positive regulation of hormone biosynthetic process IDA
Inferred from Direct Assay
more info
 
involved_in positive regulation of protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of aryl hydrocarbon receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear aryl hydrocarbon receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aryl hydrocarbon receptor nuclear translocator
Names
class E basic helix-loop-helix protein 2
dioxin receptor, nuclear translocator
hypoxia inducible factor 1 subunit beta
hypoxia-inducible factor 1, beta subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028248.1 RefSeqGene

    Range
    5170..72056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197325.2NP_001184254.1  aryl hydrocarbon receptor nuclear translocator isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK291705, AL355860, BU730937
    UniProtKB/TrEMBL
    A8K6P0
    Conserved Domains (5) summary
    smart00091
    Location:151215
    PAS; PAS domain
    cd00130
    Location:347443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:76128
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:148254
    PAS; PAS fold
    pfam14598
    Location:347447
    PAS_11; PAS domain
  2. NM_001286035.2NP_001272964.1  aryl hydrocarbon receptor nuclear translocator isoform 5

    See identical proteins and their annotated locations for NP_001272964.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' region, initiates translation at a downstream in-frame start codon, and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AK223459, AK293027, AL355860, AL834279, BU730937
    Consensus CDS
    CCDS65641.1
    UniProtKB/TrEMBL
    B0AZM1
    Related
    ENSP00000423851.1, ENST00000515192.5
    Conserved Domains (6) summary
    smart00091
    Location:157221
    PAS; PAS domain
    cd00130
    Location:348444
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:82134
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:154260
    PAS; PAS fold
    pfam11593
    Location:509720
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:348448
    PAS_11; PAS domain
  3. NM_001286036.2NP_001272965.1  aryl hydrocarbon receptor nuclear translocator isoform 6

    See identical proteins and their annotated locations for NP_001272965.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AB209877, AK223459, AK293027, AL355860, BU730937
    Consensus CDS
    CCDS65642.1
    UniProtKB/TrEMBL
    B0AZM1
    Related
    ENSP00000346372.2, ENST00000354396.6
    Conserved Domains (3) summary
    cd18947
    Location:86150
    bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
    pfam00989
    Location:163269
    PAS; PAS fold
    pfam14598
    Location:362462
    PAS_11; PAS domain
  4. NM_001350224.2NP_001337153.1  aryl hydrocarbon receptor nuclear translocator isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate exon in the 5' region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK293027, AL355860, BC041121, BU730937
    UniProtKB/TrEMBL
    B0AZM1
    Conserved Domains (4) summary
    pfam00010
    Location:82134
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:154260
    PAS; PAS fold
    pfam11593
    Location:514725
    Med3; Mediator complex subunit 3 fungal
    cl25986
    Location:353453
    PAS_3; PAS fold
  5. NM_001350225.2NP_001337154.1  aryl hydrocarbon receptor nuclear translocator isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in its 5' coding region, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (8) has a slightly shorter, but distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK293027, AL355860, BC041121, BU730937
    UniProtKB/TrEMBL
    B4E3L5
    Conserved Domains (4) summary
    pfam00010
    Location:90142
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:162268
    PAS; PAS fold
    pfam11593
    Location:522733
    Med3; Mediator complex subunit 3 fungal
    cl25986
    Location:361461
    PAS_3; PAS fold
  6. NM_001350226.2NP_001337155.1  aryl hydrocarbon receptor nuclear translocator isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses an alternate splice site in its 5' coding region, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (8) has a slightly shorter, but distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK293027, AL355860, BC041121, BU730937
    UniProtKB/TrEMBL
    B4E3L5
    Conserved Domains (4) summary
    pfam00010
    Location:89141
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:161267
    PAS; PAS fold
    pfam11593
    Location:521732
    Med3; Mediator complex subunit 3 fungal
    cl25986
    Location:360460
    PAS_3; PAS fold
  7. NM_001668.4NP_001659.1  aryl hydrocarbon receptor nuclear translocator isoform 1

    See identical proteins and their annotated locations for NP_001659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK293027, AL355860, BC041121, BU730937
    Consensus CDS
    CCDS970.1
    UniProtKB/Swiss-Prot
    B2R9H1, C4AMA1, F8WAP6, P27540, Q59ED4, Q5QP39, Q8NDC7
    UniProtKB/TrEMBL
    B0AZM1
    Related
    ENSP00000351407.5, ENST00000358595.10
    Conserved Domains (6) summary
    smart00091
    Location:166230
    PAS; PAS domain
    cd00130
    Location:362458
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163269
    PAS; PAS fold
    pfam11593
    Location:523734
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:362462
    PAS_11; PAS domain
  8. NM_178427.3NP_848514.1  aryl hydrocarbon receptor nuclear translocator isoform 3

    See identical proteins and their annotated locations for NP_848514.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK315812, AL355860, BU730937
    Consensus CDS
    CCDS971.1
    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
    Related
    ENSP00000427571.1, ENST00000505755.5
    Conserved Domains (6) summary
    smart00091
    Location:151215
    PAS; PAS domain
    cd00130
    Location:347443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:76128
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:148254
    PAS; PAS fold
    pfam11593
    Location:508719
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:347447
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    150809713..150876599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420740.1XP_047276696.1  aryl hydrocarbon receptor nuclear translocator isoform X29

    UniProtKB/TrEMBL
    A8K6P0
  2. XM_047420734.1XP_047276690.1  aryl hydrocarbon receptor nuclear translocator isoform X28

    UniProtKB/TrEMBL
    A8K6P0
  3. XM_047420716.1XP_047276672.1  aryl hydrocarbon receptor nuclear translocator isoform X20

    UniProtKB/TrEMBL
    A8K6P0
  4. XM_047420715.1XP_047276671.1  aryl hydrocarbon receptor nuclear translocator isoform X19

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  5. XM_047420727.1XP_047276683.1  aryl hydrocarbon receptor nuclear translocator isoform X27

    UniProtKB/TrEMBL
    A8K6P0
  6. XM_017001296.2XP_016856785.1  aryl hydrocarbon receptor nuclear translocator isoform X26

    UniProtKB/TrEMBL
    A8K6P0
  7. XM_047420719.1XP_047276675.1  aryl hydrocarbon receptor nuclear translocator isoform X25

    UniProtKB/TrEMBL
    A8K6P0
  8. XM_017001295.2XP_016856784.1  aryl hydrocarbon receptor nuclear translocator isoform X24

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  9. XM_047420711.1XP_047276667.1  aryl hydrocarbon receptor nuclear translocator isoform X16

    UniProtKB/TrEMBL
    A8K6P0
  10. XM_005245153.2XP_005245210.1  aryl hydrocarbon receptor nuclear translocator isoform X15

    UniProtKB/TrEMBL
    B0AZM1
    Conserved Domains (6) summary
    smart00091
    Location:166230
    PAS; PAS domain
    cd00130
    Location:357453
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163269
    PAS; PAS fold
    pfam11593
    Location:518729
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:357457
    PAS_11; PAS domain
  11. XM_017001294.2XP_016856783.1  aryl hydrocarbon receptor nuclear translocator isoform X23

    UniProtKB/TrEMBL
    A8K6P0
  12. XM_005245157.2XP_005245214.1  aryl hydrocarbon receptor nuclear translocator isoform X22

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
    Conserved Domains (6) summary
    smart00091
    Location:166230
    PAS; PAS domain
    cd00130
    Location:362458
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163269
    PAS; PAS fold
    pfam11593
    Location:486697
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:362462
    PAS_11; PAS domain
  13. XM_005245151.3XP_005245208.1  aryl hydrocarbon receptor nuclear translocator isoform X12

    UniProtKB/TrEMBL
    A8K6P0
    Conserved Domains (5) summary
    smart00091
    Location:166230
    PAS; PAS domain
    cd00130
    Location:362458
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163269
    PAS; PAS fold
    pfam14598
    Location:362462
    PAS_11; PAS domain
  14. XM_047420697.1XP_047276653.1  aryl hydrocarbon receptor nuclear translocator isoform X7

    UniProtKB/TrEMBL
    A8K6P0
  15. XM_047420694.1XP_047276650.1  aryl hydrocarbon receptor nuclear translocator isoform X6

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  16. XM_017001293.2XP_016856782.1  aryl hydrocarbon receptor nuclear translocator isoform X11

    UniProtKB/TrEMBL
    A8K6P0
  17. XM_047420701.1XP_047276657.1  aryl hydrocarbon receptor nuclear translocator isoform X10

    UniProtKB/TrEMBL
    A8K6P0
  18. XM_017001291.2XP_016856780.1  aryl hydrocarbon receptor nuclear translocator isoform X5

    UniProtKB/TrEMBL
    A8K6P0
  19. XM_017001290.3XP_016856779.1  aryl hydrocarbon receptor nuclear translocator isoform X4

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  20. XM_047420692.1XP_047276648.1  aryl hydrocarbon receptor nuclear translocator isoform X3

    UniProtKB/TrEMBL
    A8K6P0
  21. XM_017001289.2XP_016856778.1  aryl hydrocarbon receptor nuclear translocator isoform X2

    UniProtKB/TrEMBL
    B0AZM1
    Conserved Domains (6) summary
    smart00091
    Location:157221
    PAS; PAS domain
    cd00130
    Location:348444
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:82134
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:154260
    PAS; PAS fold
    pfam11593
    Location:509720
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:348448
    PAS_11; PAS domain
  22. XM_047420700.1XP_047276656.1  aryl hydrocarbon receptor nuclear translocator isoform X9

    UniProtKB/TrEMBL
    A8K6P0
  23. XM_017001292.2XP_016856781.1  aryl hydrocarbon receptor nuclear translocator isoform X8

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  24. XM_017001288.3XP_016856777.1  aryl hydrocarbon receptor nuclear translocator isoform X1

    UniProtKB/TrEMBL
    A8K6P0
  25. XM_047420713.1XP_047276669.1  aryl hydrocarbon receptor nuclear translocator isoform X18

    UniProtKB/TrEMBL
    B4E3L5
  26. XM_047420709.1XP_047276665.1  aryl hydrocarbon receptor nuclear translocator isoform X14

    UniProtKB/TrEMBL
    B4E3L5
  27. XM_047420743.1XP_047276699.1  aryl hydrocarbon receptor nuclear translocator isoform X30

    UniProtKB/TrEMBL
    B4E3L5
  28. XM_047420712.1XP_047276668.1  aryl hydrocarbon receptor nuclear translocator isoform X17

    UniProtKB/TrEMBL
    B4E3L5
  29. XM_011509543.4XP_011507845.1  aryl hydrocarbon receptor nuclear translocator isoform X13

    See identical proteins and their annotated locations for XP_011507845.1

    UniProtKB/TrEMBL
    B4E3L5
    Conserved Domains (4) summary
    pfam00010
    Location:90142
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:162268
    PAS; PAS fold
    pfam11593
    Location:522733
    Med3; Mediator complex subunit 3 fungal
    cl25986
    Location:361461
    PAS_3; PAS fold
  30. XM_011509546.3XP_011507848.1  aryl hydrocarbon receptor nuclear translocator isoform X21

    UniProtKB/TrEMBL
    B0AZM1
    Conserved Domains (6) summary
    smart00091
    Location:134198
    PAS; PAS domain
    cd00130
    Location:330426
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:59111
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:131237
    PAS; PAS fold
    pfam11593
    Location:491702
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:330430
    PAS_11; PAS domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    149933391..150000287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336623.1XP_054192598.1  aryl hydrocarbon receptor nuclear translocator isoform X29

    UniProtKB/TrEMBL
    A8K6P0
  2. XM_054336622.1XP_054192597.1  aryl hydrocarbon receptor nuclear translocator isoform X28

    UniProtKB/TrEMBL
    A8K6P0
  3. XM_054336614.1XP_054192589.1  aryl hydrocarbon receptor nuclear translocator isoform X20

    UniProtKB/TrEMBL
    A8K6P0
  4. XM_054336613.1XP_054192588.1  aryl hydrocarbon receptor nuclear translocator isoform X19

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  5. XM_054336621.1XP_054192596.1  aryl hydrocarbon receptor nuclear translocator isoform X27

    UniProtKB/TrEMBL
    A8K6P0
  6. XM_054336620.1XP_054192595.1  aryl hydrocarbon receptor nuclear translocator isoform X26

    UniProtKB/TrEMBL
    A8K6P0
  7. XM_054336619.1XP_054192594.1  aryl hydrocarbon receptor nuclear translocator isoform X25

    UniProtKB/TrEMBL
    A8K6P0
  8. XM_054336618.1XP_054192593.1  aryl hydrocarbon receptor nuclear translocator isoform X24

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  9. XM_054336610.1XP_054192585.1  aryl hydrocarbon receptor nuclear translocator isoform X16

    UniProtKB/TrEMBL
    A8K6P0
  10. XM_054336609.1XP_054192584.1  aryl hydrocarbon receptor nuclear translocator isoform X15

    UniProtKB/TrEMBL
    B0AZM1
  11. XM_054336617.1XP_054192592.1  aryl hydrocarbon receptor nuclear translocator isoform X23

    UniProtKB/TrEMBL
    A8K6P0
  12. XM_054336616.1XP_054192591.1  aryl hydrocarbon receptor nuclear translocator isoform X22

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  13. XM_054336608.1XP_054192583.1  aryl hydrocarbon receptor nuclear translocator isoform X12

    UniProtKB/TrEMBL
    A8K6P0
  14. XM_054336603.1XP_054192578.1  aryl hydrocarbon receptor nuclear translocator isoform X7

    UniProtKB/TrEMBL
    A8K6P0
  15. XM_054336602.1XP_054192577.1  aryl hydrocarbon receptor nuclear translocator isoform X6

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  16. XM_054336607.1XP_054192582.1  aryl hydrocarbon receptor nuclear translocator isoform X11

    UniProtKB/TrEMBL
    A8K6P0
  17. XM_054336606.1XP_054192581.1  aryl hydrocarbon receptor nuclear translocator isoform X10

    UniProtKB/TrEMBL
    A8K6P0
  18. XM_054336601.1XP_054192576.1  aryl hydrocarbon receptor nuclear translocator isoform X5

    UniProtKB/TrEMBL
    A8K6P0
  19. XM_054336600.1XP_054192575.1  aryl hydrocarbon receptor nuclear translocator isoform X4

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  20. XM_054336599.1XP_054192574.1  aryl hydrocarbon receptor nuclear translocator isoform X3

    UniProtKB/TrEMBL
    A8K6P0
  21. XM_054336598.1XP_054192573.1  aryl hydrocarbon receptor nuclear translocator isoform X2

    UniProtKB/TrEMBL
    B0AZM1
  22. XM_054336605.1XP_054192580.1  aryl hydrocarbon receptor nuclear translocator isoform X9

    UniProtKB/TrEMBL
    A8K6P0
  23. XM_054336604.1XP_054192579.1  aryl hydrocarbon receptor nuclear translocator isoform X8

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
  24. XM_054336597.1XP_054192572.1  aryl hydrocarbon receptor nuclear translocator isoform X1

    UniProtKB/TrEMBL
    A8K6P0
  25. XM_054336612.1XP_054192587.1  aryl hydrocarbon receptor nuclear translocator isoform X18

    UniProtKB/TrEMBL
    B4E3L5
  26. XM_054336624.1XP_054192599.1  aryl hydrocarbon receptor nuclear translocator isoform X30

    UniProtKB/TrEMBL
    B4E3L5
  27. XM_054336611.1XP_054192586.1  aryl hydrocarbon receptor nuclear translocator isoform X17

    UniProtKB/TrEMBL
    B4E3L5
  28. XM_054336615.1XP_054192590.1  aryl hydrocarbon receptor nuclear translocator isoform X21

    UniProtKB/TrEMBL
    B0AZM1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178426.1: Suppressed sequence

    Description
    NM_178426.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.