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Iqgap3 IQ motif containing GTPase activating protein 3 [ Mus musculus (house mouse) ]

Gene ID: 404710, updated on 19-Jun-2024

Summary

Official Symbol
Iqgap3provided by MGI
Official Full Name
IQ motif containing GTPase activating protein 3provided by MGI
Primary source
MGI:MGI:3028642
See related
Ensembl:ENSMUSG00000028068 AllianceGenome:MGI:3028642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D030034H08
Summary
Enables small GTPase binding activity. Acts upstream of or within several processes, including intracellular signal transduction; positive regulation of macromolecule metabolic process; and positive regulation of mammary gland epithelial cell proliferation. Located in cell-cell junction; cytoplasm; and lateral plasma membrane. Orthologous to human IQGAP3 (IQ motif containing GTPase activating protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 10.4), CNS E11.5 (RPKM 6.6) and 22 other tissues See more
Orthologs
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Genomic context

See Iqgap3 in Genome Data Viewer
Location:
3 F1; 3 38.78 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87989309..88028355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88082002..88121048)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene NAD(P)HX epimerase Neighboring gene STARR-positive B cell enhancer ABC_E10192 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene STARR-positive B cell enhancer ABC_E10193 Neighboring gene STARR-positive B cell enhancer ABC_E1621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87942601-87942788 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87945923-87946106 Neighboring gene STARR-positive B cell enhancer ABC_E2075 Neighboring gene myocyte enhancer factor 2D Neighboring gene RIKEN cDNA 1700113A16 gene Neighboring gene expressed sequence AI849053

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC32192

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables myosin VI light chain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras GTPase-activating-like protein IQGAP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033484.1NP_001028656.1  ras GTPase-activating-like protein IQGAP3

    See identical proteins and their annotated locations for NP_001028656.1

    Status: VALIDATED

    Source sequence(s)
    BC068159, CA750580, CX200367
    Consensus CDS
    CCDS38478.1
    UniProtKB/TrEMBL
    B9EKT6, F8VQ29
    Related
    ENSMUSP00000071715.6, ENSMUST00000071812.11
    Conserved Domains (5) summary
    smart00015
    Location:764782
    IQ; Calmodulin-binding motif
    smart00323
    Location:9771328
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:35147
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam03836
    Location:14341555
    RasGAP_C; RasGAP C-terminus
    cl02569
    Location:9881337
    RasGAP; Ras GTPase Activating Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87989309..88028355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501643.3XP_006501706.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    UniProtKB/TrEMBL
    B9EKT6
    Conserved Domains (4) summary
    smart00015
    Location:501519
    IQ; Calmodulin-binding motif
    COG5261
    Location:5991369
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    cd00201
    Location:408433
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl02569
    Location:7251074
    RasGAP; Ras GTPase Activating Domain