IL12B interleukin 12B [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: IL12Bprovided by CGNC
Official Full Name: interleukin 12Bprovided by CGNC
Primary source: CGNC:966
See related: Ensembl:ENSGALG00010009374
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: IL-12; IL-12B; ChIL-12; IL-12p40
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (7703669..7779521)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (7674671..7784489)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results indicate that ChIL-23 is a member of the IL-12 family, has proinflammatory properties related to IL-23R and IL-12Rbeta1 receptor expression, and activates the JAK/STAT signaling pathway that results in the interaction of ChIL-23alpha with ChIL-12p40 to form the novel ChIL-23 complex.
Title: Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex.
The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12beta, and IL-1beta were decreased in the experiment.
Title: Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks.
A high serum interleukin-12p40 level prior to Kasai surgery predict a favourable outcome in children with biliary atresia.
Title: A high serum interleukin-12p40 level prior to Kasai surgery predict a favourable outcome in children with biliary atresia.
molecular cloning; IL-12 p40 mRNA expression was identified in a wide variety of tissues and in B, T, and macrophage cell lines
Title: Avian interleukin-12beta (p40): cloning and characterization of the cDNA and gene.
The high degree of functional similarity between chicken IL-12p40 and that of higher vertebrates, despite poor sequence homology, illustrates the conservation of IL-12 since the evolutionary dichotomy of birds and mammals >300 million years ago.
Title: Identification and molecular cloning of functional chicken IL-12.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immunoglobulin mediated immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-12 subunit beta

Names: IL-12 p40 subunit; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; interleukin-12 p40 subunit; interleukin-12p40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.