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med8 mediator complex subunit 8 [ Danio rerio (zebrafish) ]

Gene ID: 404615, updated on 9-Sep-2025
Official Symbol
med8provided by ZNC
Official Full Name
mediator complex subunit 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2091
See related
Ensembl:ENSDARG00000114425 AllianceGenome:ZFIN:ZDB-GENE-040426-2091
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:76877
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED8 (mediator complex subunit 8). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See med8 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (3121539..3154108, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (2422585..2454122, complement)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene regulator of G protein signaling like 1 Neighboring gene uncharacterized LOC141386157 Neighboring gene pre-B-cell leukemia homeobox 1b Neighboring gene uncharacterized LOC101882644 Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene hydroxypyruvate isomerase Neighboring gene protein tyrosine phosphatase receptor type Fa Neighboring gene uncharacterized LOC137495906

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Wang D, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17640903, Free PMC Article
  2. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC76877

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
mediator of RNA polymerase II transcription subunit 8

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207083.1 → NP_996966.1  mediator of RNA polymerase II transcription subunit 8

    See identical proteins and their annotated locations for NP_996966.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066472
    UniProtKB/Swiss-Prot
    Q6NYT1
    Related
    ENSDARP00000149277.1, ENSDART00000192820.1
    Conserved Domains (1) summary
    pfam10232
    Location:3 → 264
    Med8; Mediator of RNA polymerase II transcription complex subunit 8

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    3121539..3154108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYT1.1 GenPept UniProtKB/Swiss-Prot:Q6NYT1

Gene LinkOut

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