GDF9 growth differentiation factor 9 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: GDF9provided by CGNC
Official Full Name: growth differentiation factor 9provided by CGNC
Primary source: CGNC:5353
See related: Ensembl:ENSGALG00010013676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: GDF-9
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (16672354..16675091)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (16684470..16687199)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

373 Jinghai Yellow chickens were chosen randomly to detect SNPs in GDF9 by PCR-SSCP and DNA sequencing methods. four SNPs (g.2053G > A, g.2275T > C, g.2338C > T, g.2420T > C) in total had been detected. Amongst them, g.2420T > C was first found significantly associated with reproduction trait in chickens and heterozygous type C2T2 had higher average egg weight at 300 days of age (AEWD300) than T2T2.
Title: Polymorphism identification in GDF9 gene and its association analysis with reproduction traits in Jinghai Yellow chicken.
These results provided further evidence that the GDF9 gene is involved in determining reproductive traits in chicken.
Title: Polymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traits.
The BMP15 SNP C34T had an effect on total egg production at 300 d of age (EN) and age at first laying (AFE). The GDF9 SNP G593A affected EN and both C231T and C896T influenced AFE. The TGC1TGC1 diplotype in BMP15 had the highest EN.
Title: Polymorphism identification in BMP15 and GDF9 genes and their association with egg production in chickens.
Collectively, the two SNPs identified in this study (A238G for FOXL2 and G1609T for GDF9) might be used as possible genetic molecular markers to aid in the improvement of egg production traits in chicken breeding.
Title: Association of novel polymorphisms of forkhead box L2 and growth differentiation factor-9 genes with egg production traits in local Chinese Dagu hens.
GDF9 is present in the oocyte, and this factor is capable of enhancing granulosa cell proliferation, as has been demonstrated in mammals.
Title: Expression and function of growth differentiation factor-9 in an oviparous species, Gallus domesticus.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: growth/differentiation factor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_206988.3 → NP_996871.3 growth/differentiation factor 9 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000256

UniProtKB/TrEMBL

A0A8V0YTB1, Q6DKY0

Related

ENSGALP00010019460.1, ENSGALT00010032870.1

Conserved Domains (1) summary

cd19403
Location:352 → 457

TGF_beta_GDF9; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins