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P5CDh1 delta-1-Pyrroline-5-carboxylate dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40434, updated on 2-Nov-2024

Summary

Official Symbol
P5CDh1provided by FlyBase
Official Full Name
delta-1-Pyrroline-5-carboxylate dehydrogenase 1provided by FlyBase
Primary source
FLYBASE:FBgn0037138
Locus tag
Dmel_CG7145
See related
AllianceGenome:FB:FBgn0037138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7145; Dmel\CG7145; DmP5CDh1; P5CDh
Summary
Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Involved in proline metabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Used to study hyperprolinemia type 2. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See P5CDh1 in Genome Data Viewer
Location:
78F4-78F4; 3-47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21836665..21841356, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21829765..21834456, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Nopp140 Neighboring gene transfer RNA:Cysteine-GCA 4-1 Neighboring gene uncharacterized protein Neighboring gene mushroom-body expressed

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-pyrroline-5-carboxylate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-pyrroline-5-carboxylate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proline catabolic process to glutamate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proline catabolic process to glutamate IEA
Inferred from Electronic Annotation
more info
 
involved_in proline metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
delta-1-Pyrroline-5-carboxylate dehydrogenase 1
Names
CG7145-PA
CG7145-PB
CG7145-PD
CG7145-PE
CG7145-PF
P5CDh1-PA
P5CDh1-PB
P5CDh1-PD
P5CDh1-PE
P5CDh1-PF
delta-1-pyrroline-5-carboxylate dehydrogenase
NP_001189159.1
NP_001262196.1
NP_649368.2
NP_730695.1
NP_730698.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21836665..21841356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168945.5NP_730698.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Related
    FBpp0078101
    Conserved Domains (1) summary
    cd07123
    Location:41563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
  2. NM_168942.5NP_730695.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730695.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Related
    FBpp0078099
    Conserved Domains (1) summary
    cd07123
    Location:41563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
  3. NM_001275267.1NP_001262196.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Conserved Domains (1) summary
    cd07123
    Location:41563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
  4. NM_001202230.2NP_001189159.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189159.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Conserved Domains (1) summary
    cd07123
    Location:41563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
  5. NM_141111.6NP_649368.2  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649368.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Related
    FBpp0078100
    Conserved Domains (1) summary
    cd07123
    Location:41563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17