CRH corticotropin releasing hormone [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CRHprovided by CGNC
Official Full Name: corticotropin releasing hormoneprovided by CGNC
Primary source: CGNC:11573
See related: Ensembl:ENSGALG00010004133
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CRF; corticoliberin
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (114715007..114716000, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (114725839..114726832, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results provide insights into the molecular basis of eating disorders and suggest that CRF corticotrophin-releasing factor in the paraventricular nucleus may exacerbate the anorexic phenotype in the presence of environmental stressors.
Title: Stress-induced suppression of neuropeptide Y-induced hunger in anorexic chicks involves corticotrophin-releasing factor signalling and the paraventricular nucleus of the hypothalamus.
Results demonstrate a potential role for CRH in determining the heat stress resilience/vulnerability balance
Title: The balance between stress resilience and vulnerability is regulated by corticotropin-releasing hormone during the critical postnatal period for sensory development.
results suggest that UCN-3 regulates food intake, body temperature, and gastric emptying via the CRH-R2 in the brain of chicks, and these effects were similar to those induced by CRH.
Title: Comparison of brain urocortin-3 and corticotrophin-releasing factor for physiological responses in chicks.
The results indicate that the 2 genes show different response to cold stress at the mRNA levels, and on the other hand, the different degree of cold stress also produces different effects on the identical gene.
Title: Effects of cold stress on the messenger ribonucleic acid levels of corticotrophin-releasing hormone and thyrotropin-releasing hormone in hypothalami of broilers.
ghrelin inhibits food intake by interacting with the endogenous corticotropin-releasing factor and its receptor
Title: Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks.
CRH in the diencephalon increased, whereas peptide content in median eminence decreased just before hatching. Release and biosynthesis may be coupled. Plasma corticosterone significantly increased between embryonic d 20 and the first day post hatch.
Title: Molecular cloning and developmental expression of corticotropin-releasing factor in the chicken.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of epinephrine secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of glucagon secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cortisol secretion	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: corticoliberin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123031.1 → NP_001116503.1 corticoliberin precursor

See identical proteins and their annotated locations for NP_001116503.1

Status: PROVISIONAL

Source sequence(s)

AJ621492

UniProtKB/TrEMBL

Q703P0

Related

ENSGALP00010005659.1, ENSGALT00010009638.1

Conserved Domains (1) summary

pfam00473
Location:128 → 165

CRF; Corticotropin-releasing factor family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

114715007..114716000 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

114725839..114726832 complement

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GenBank, FASTA, Sequence Viewer (Graphics)