IL1B interleukin 1 beta [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IL1Bprovided by VGNC
Official Full Name: interleukin 1 betaprovided by VGNC
Primary source: VGNC:VGNC:41957
See related: Ensembl:ENSCAFG00845011661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: IL-1
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	17	NC_051821.1 (37794784..37800390, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	17	NC_006599.4 (36788618..36793136, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	17	NC_049238.1 (37201034..37205552, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	17	NC_049277.1 (36930880..36935397, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	17	NC_049758.1 (36987147..36991665, complement)
105	previous assembly	CanFam3.1 (GCF_000002285.3)	17	NC_006599.3 (37019329..37033388, complement)

Chromosome 17 - NC_051821.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the regulation of the expression and function of NGAL in IL-1beta-treated Madin-Darby canine kidney (MDCK) cells, was investigated.
Title: Expression and Function of Interleukin-1β-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells.
These findings suggest that stimulation of MEK/ERK signaling pathway by NF-kappaB activation regulates IL-1beta-induced COX-2 expression and subsequent prostaglandin E2 release in canine dermal fibroblasts.
Title: Activation of MEK/ERK pathways through NF-κB activation is involved in interleukin-1β-induced cyclooxygenease-2 expression in canine dermal fibroblasts.
Fatal outcome from pulmonary hemorrhages in dogs with leptospirosis was associated with low TNF-alpha, high IL-1beta, and high iNOS expression.
Title: Expression Profile of Cytokines and Enzymes mRNA in Blood Leukocytes of Dogs with Leptospirosis and Its Associated Pulmonary Hemorrhage Syndrome.
IL-1beta splice variant 1 (IL-1betasv1) was significantly up-regulated in failing myocardium of dogs suffering from chronic degenerative valvular disease
Title: Anti-inflammatory properties and expression in selected organs of canine interleukin-1β splice variant 1.
after flexor tendon injury, a greater than 4,000-fold up-regulation in the expression of IL-1beta was observed
Title: The early inflammatory response after flexor tendon healing: a gene expression and histological analysis.
This study showed that the IL-1Ra:IL-1beta protein ratio was negatively correlated with clinical severity in dogs with inflammatory bowel disease.
Title: Mucosal imbalance of interleukin-1β and interleukin-1 receptor antagonist in canine inflammatory bowel disease.
canine IL-1beta gene can be transcribed in two ways in heart tissue
Title: Increased expression of interleukin-1beta and its novel splice variant in canine hearts with volume overload.
mRNA and protein structures and identities of the present known mammalian IL1B.
Title: Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians.
Inflammatory cytokines and NO may be involved in intraneural inflammatory changes arising from mechanical compression
Title: Localization and changes of intraneural inflammatory cytokines and inducible-nitric oxide induced by mechanical compression.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

IL1B (e-PCR), detects polymorphism
- UniSTS:264073

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fever generation	IEA Inferred from Electronic Annotation more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: interleukin-1 beta

Names: IL-1 beta; interleukin-1 beta proprotein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037971.1 → NP_001033060.1 interleukin-1 beta

See identical proteins and their annotated locations for NP_001033060.1

Status: PROVISIONAL

Source sequence(s)

DQ251036

UniProtKB/TrEMBL

A0A8C0KX92, A0A8C0M969, F1PTU3, Q2VCE2

Related

ENSCAFP00845016238.1, ENSCAFT00845020705.1

Conserved Domains (2) summary

smart00125
Location:116 → 262

IL1; Interleukin-1 homologues

pfam02394
Location:1 → 100

IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051821.1 Reference ROS_Cfam_1.0

Range

37794784..37800390 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038690464.1 → XP_038546392.1 interleukin-1 beta isoform X1

UniProtKB/TrEMBL

A0A8C0KX92, A0A8C0M969, F1PTU3

Conserved Domains (2) summary

smart00125
Location:116 → 262

IL1; Interleukin-1 homologues

pfam02394
Location:1 → 100

IL1_propep; Interleukin-1 propeptide