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KLK2 kallikrein-related peptidase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 403967, updated on 27-Jun-2026
Gene symbol
KLK2
Gene description
kallikrein-related peptidase 2
See related
Ensembl:ENSCAFG00845015496 RGD:12294974
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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Try the new Transcripts and proteins table
See KLK2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (106493212..106517683, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (105556090..105559329, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (106600940..106604175, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (106163839..106167074, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (105805387..105808628, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 4 Neighboring gene kallikrein-1-like Neighboring gene tubulin beta chain-like Neighboring gene kallikrein-15 Neighboring gene kallikrein-15-like Neighboring gene kallikrein 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid sequencing. Lazure C, et al. FEBS Lett, 1984 Sep 17. PMID 6566614
  2. Androgen regulation of canine prostatic arginine esterase mRNA using cloned cDNA. Chapdelaine P, et al. Mol Cell Endocrinol, 1988 Mar. PMID 3371547
  3. Nucleotide sequence of the androgen-dependent arginine esterase mRNA of canine prostate. Chapdelaine P, et al. FEBS Lett, 1988 May 9. PMID 2835268
  4. Characterization and expression of the prostatic arginine esterase gene, a canine glandular kallikrein. Chapdelaine P, et al. DNA Cell Biol, 1991 Jan-Feb. PMID 1991049
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
arginine esterase
Names
kallikrein 2, prostatic
NP_001003284.1
XP_038509359.1
XP_038509360.1
XP_038509361.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003284.1 → NP_001003284.1  arginine esterase precursor

    See identical proteins and their annotated locations for NP_001003284.1

    Status: PROVISIONAL

    Source sequence(s)
    Y00751
    UniProtKB/Swiss-Prot
    P09582
    Related
    ENSCAFP00845021773.1, ENSCAFT00845027665.1
    Conserved Domains (2) summary
    smart00020
    Location:24 → 252
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25 → 255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    106493212..106517683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653431.1 → XP_038509359.1  arginine esterase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NWV7, A0A8I3NXG0
    Related
    ENSCAFP00845021760.1, ENSCAFT00845027649.1
    Conserved Domains (1) summary
    cd00190
    Location:121 → 307
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_038653432.1 → XP_038509360.1  arginine esterase isoform X2

    Conserved Domains (1) summary
    smart00020
    Location:32 → 260
    Tryp_SPc; Trypsin-like serine protease

  3. XM_038653433.1 → XP_038509361.1  arginine esterase isoform X2

    Conserved Domains (1) summary
    smart00020
    Location:32 → 260
    Tryp_SPc; Trypsin-like serine protease

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    106163839..106167074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    105805387..105808628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    106600940..106604175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    105556090..105559329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09582.1 GenPept UniProtKB/Swiss-Prot:P09582

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