RAB11A RAB11A, member RAS oncogene family [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: RAB11Aprovided by VGNC
Official Full Name: RAB11A, member RAS oncogene familyprovided by VGNC
Primary source: VGNC:VGNC:45248
See related: Ensembl:ENSCAFG00845027320 RGD:12230130
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: RAB11
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 30

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	30	NC_051834.1 (30390944..30408531)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	30	NC_006612.4 (30128206..30145797)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	30	NC_049251.1 (30624755..30642365)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	30	NC_049290.1 (30320666..30338234)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	30	NC_049771.1 (30383756..30401404)

Chromosome 30 - NC_051834.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We conclude that TBC1D9B is a Rab11a GAP that regulates basolateral-to-apical transcytosis in polarized MDCK cells
Title: TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells.
Rab11a regulates sorting at apical recycling endosomes and is also implicated in carrier vesicle docking at the apical plasma membrane.
Title: Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates.
It was shown that caveolin-1-containing vesicles define a compartment that partially overlaps with Rab11a, and that the distribution of subapical caveolin-1 and Rab11a shows a similar dependence on microtubule disruption.
Title: Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells.
These results suggest that the progeny vRNP makes use of Rab11-dependent recycling endosome machinery for apical plasma membrane trafficking.
Title: Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome.

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General gene information

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Markers

AI602490 (e-PCR)
- UniSTS:245148

RH80236 (e-PCR)
- UniSTS:83908

RAB11A (e-PCR)
- UniSTS:264165

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in melanosome transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic recycling endosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-11A

Names: rab-11; rab11 GTP-binding protein

NP_001003276.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.