TNF tumor necrosis factor [ Canis lupus familiaris (dog) ]

Gene ID: 403922, updated on 4-Apr-2023

Summary

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Official Symbol: TNFprovided by VGNC
Official Full Name: tumor necrosis factorprovided by VGNC
Primary source: VGNC:VGNC:47647
See related: Ensembl:ENSCAFG00845010558
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: TNFA; cTNF; TNLG1F
Orthologs: human mouse all
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Genomic context

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See TNF in Genome Data Viewer

Location:: chromosome: 12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	12	NC_051816.1 (1219807..1221672)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	12	NC_006594.4 (1211002..1212867)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	12	NC_049233.1 (1213251..1215120)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	12	NC_049272.1 (1078543..1080407)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	12	NC_049753.1 (1146468..1148336)
105	previous assembly	CanFam3.1 (GCF_000002285.3)	12	NC_006594.3 (1074561..1076425)

Chromosome 12 - NC_051816.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

two SNPs of the TNF gene are associated with obesity in Labrador dogs
Title: Sequence analysis of three canine adipokine genes revealed an association between TNF polymorphisms and obesity in Labrador dogs.
Fatal outcome from pulmonary hemorrhages in dogs with leptospirosis was associated with low TNF-alpha, high IL-1beta, and high iNOS expression.
Title: Expression Profile of Cytokines and Enzymes mRNA in Blood Leukocytes of Dogs with Leptospirosis and Its Associated Pulmonary Hemorrhage Syndrome.
This diminished TNF-alpha, IL-6 and iNOS expression, and NO production was in parallel to the respective decreased NF-kappaB p65 protein nuclear translocation in the LPS-activated canine PBMCs pretreated with 25 microM and 50 microM propofol.
Title: Propofol attenuates LPS-induced tumor necrosis factor-α, interleukin-6 and nitric oxide expression in canine peripheral blood mononuclear cells possibly through down-regulation of nuclear factor (NF)-κB activation.
Tumour necrosis factor (TNF)-alpha expression was observed in vascular endothelial cells in both neoplastic and normal kidney.
Title: Angiogenesis and expression of vascular endothelial growth factor, tumour necrosis factor-α and hypoxia inducible factor-1α in canine renal cell carcinoma.
The observed HMGB1 release kinetics showed a clearly time-dependent manner with a peak release 24h after TNF-alpha stimulation, while stimulation with IFN-gamma had only small effects on the HMGB1 release.
Title: TNF-α induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A).
the TNF-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular cells is mediated through Src- and TACE-dependent EGFR activation.
Title: The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.
The replication characteristics of H3N8 influenza virus and its effects on protein expression of canine alveolar macrophages are reported; only TNF-alpha levels were significantly increased 12 h after inoculation.
Title: Canine influenza virus replicates in alveolar macrophages and induces TNF-alpha.
The usefulness of HSP27, HSP70, and TNF-alpha as biological markers for canine skin diseases was studied.
Title: Evaluation of HSP70, 27 and TNF-alpha expression [corrected] in different canine cutaneous and gland diseases.
the ERK/GEF-H1/Rho/Rho kinase/phospho-MLC pathway is the mechanism mediating TNF-alpha-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury
Title: GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.
findings suggest that susceptibility to Anal furunculosis in German Shepherd dogs is primarily associated with DLA-DRB1*00101 and any association with the Tumor Necrosis Factor-alpha locus is secondary and is because of linkage disequilibrium .
Title: Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

GDB:624603 (e-PCR)
- UniSTS:158353

GDB:624619 (e-PCR)
- UniSTS:158354

PMC165077P2 (e-PCR)
- UniSTS:271532

TNF (e-PCR), detects polymorphism
- UniSTS:264951

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables death receptor agonist activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in I-kappaB kinase/NF-kappaB signaling	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in antiviral innate immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in chronic inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in embryonic digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in humoral immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to wounding	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in necroptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of alkaline phosphatase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glucose import	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myosin-light-chain-phosphatase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of signaling receptor activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular wound healing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of I-kappaB phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NIK/NF-kappaB signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood microparticle formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcidiol 1-monooxygenase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chronic inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fever generation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hair follicle development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-33 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase B signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of superoxide dismutase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synoviocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation by iron	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vitamin D biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein kinase B signaling	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of branching involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in sequestering of triglyceride	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor

Names: TNF-a; TNF-alpha; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha; tumour necrosis factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.