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TNF tumor necrosis factor [ Canis lupus familiaris (dog) ]

Gene ID: 403922, updated on 4-Apr-2023

Summary

Official Symbol
TNFprovided by VGNC
Official Full Name
tumor necrosis factorprovided by VGNC
Primary source
VGNC:VGNC:47647
See related
Ensembl:ENSCAFG00845010558
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
TNFA; cTNF; TNLG1F
Orthologs
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Genomic context

See TNF in Genome Data Viewer
Location:
chromosome: 12
Exon count:
4
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (1219807..1221672)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (1211002..1212867)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (1213251..1215120)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (1078543..1080407)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (1146468..1148336)
105 previous assembly CanFam3.1 (GCF_000002285.3) 12 NC_006594.3 (1074561..1076425)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G2 Neighboring gene NFKB inhibitor like 1 Neighboring gene uncharacterized LOC111098213 Neighboring gene lymphotoxin alpha Neighboring gene uncharacterized LOC119874139 Neighboring gene lymphotoxin beta Neighboring gene leukocyte specific transcript 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables death receptor agonist activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in antiviral innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nicotine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
 
involved_in chronic inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic digestive tract development IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell proliferation involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in humoral immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response to wounding IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in necroptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of alkaline phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytokine production involved in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myosin-light-chain-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein-containing complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vascular wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of I-kappaB phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood microparticle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcidiol 1-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chronic inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fever generation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-33 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-8 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein-containing complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synoviocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translational initiation by iron IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vitamin D biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in sequestering of triglyceride IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic cup IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor
Names
TNF-a
TNF-alpha
cachectin
tumor necrosis factor (TNF superfamily, member 2)
tumor necrosis factor ligand 1F
tumor necrosis factor ligand superfamily member 2
tumor necrosis factor-alpha
tumour necrosis factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003244.4NP_001003244.4  tumor necrosis factor

    See identical proteins and their annotated locations for NP_001003244.4

    Status: PROVISIONAL

    Source sequence(s)
    DQ923808
    UniProtKB/Swiss-Prot
    P51742, Q28339
    UniProtKB/TrEMBL
    A9LMQ0
    Related
    ENSCAFP00845014504.1, ENSCAFT00845018595.1
    Conserved Domains (1) summary
    pfam00229
    Location:102233
    TNF; TNF(tumor Necrosis Factor) family

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    1219807..1221672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    1078543..1080407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    1146468..1148336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    1213251..1215120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1211002..1212867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)