U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COL4A4 collagen type IV alpha 4 chain [ Canis lupus familiaris (dog) ]

Gene ID: 403841, updated on 5-Sep-2025
Official Symbol
COL4A4provided by VGNC
Official Full Name
collagen type IV alpha 4 chainprovided by VGNC
Primary source
VGNC:VGNC:39476
See related
Ensembl:ENSCAFG00845015333 RGD:12407155
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See COL4A4 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
51
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (40097773..40223035, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (40472320..40576418, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (40052828..40157117, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (40038958..40143270, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (39873785..39983389, complement)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene rhomboid domain containing 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC102157244 Neighboring gene uncharacterized LOC102151715 Neighboring gene collagen type IV alpha 3 chain Neighboring gene uncharacterized LOC102151666

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization. Wiersma AC, et al. DNA Seq, 2005 Aug. PMID 16147883
  2. Evaluation of canine COL4A3 and COL4A4 as candidates for familial renal disease in the Norwegian elkhound. Wiersma AC, et al. J Hered, 2005. PMID 16014809
  3. Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers. O'Leary CA, et al. Anim Genet, 2009 Apr. PMID 19133935
  4. Coordinate gene expression of the alpha3, alpha4, and alpha5 chains of collagen type IV. Evidence from a canine model of X-linked nephritis with a COL4A5 gene mutation. Thorner PS, et al. J Biol Chem, 1996 Jun 7. PMID 8662866
  5. Immunohistochemical analysis of collagen types I, III, IV and alpha-actin in the urethra of sexually intact and ovariectomized beagles. Augsburger HR, et al. Int Urogynecol J Pelvic Floor Dysfunct, 2007 Sep. PMID 17206491

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables extracellular matrix structural constituent IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
collagen alpha-4(IV) chain
NP_001026988.1

Length

  • 1688

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031818.1 → NP_001026988.1  collagen alpha-4(IV) chain

    See identical proteins and their annotated locations for NP_001026988.1

    Status: PROVISIONAL

    Source sequence(s)
    AY263363
    UniProtKB/TrEMBL
    A0A8C0PEC2, A0A8P0NCD9, Q597P9
    Related
    ENSCAFP00845021704.1, ENSCAFT00845027584.1
    Conserved Domains (2) summary
    pfam01391
    Location:858 → 917
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01413
    Location:1464 → 1568
    C4; C-terminal tandem repeated domain in type 4 procollagen

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    40097773..40223035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038434526.1 → XP_038290454.1  collagen alpha-4(IV) chain isoform X2

    UniProtKB/TrEMBL
    A0A8C0PEC2, A0A8P0NCD9
    Conserved Domains (2) summary
    pfam01391
    Location:706 → 760
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01413
    Location:1375 → 1479
    C4; C-terminal tandem repeated domain in type 4 procollagen

  2. XM_038434524.1 → XP_038290452.1  collagen alpha-4(IV) chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0PEC2, A0A8I3NXU0, A0A8P0NCD9
    Conserved Domains (3) summary
    PRK07764
    Location:810 → 1007
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam01391
    Location:795 → 849
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01413
    Location:1464 → 1568
    C4; C-terminal tandem repeated domain in type 4 procollagen

  3. XM_038434525.1 → XP_038290453.1  collagen alpha-4(IV) chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0PEC2, A0A8I3NXU0, A0A8P0NCD9
    Conserved Domains (3) summary
    PRK07764
    Location:810 → 1007
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam01391
    Location:795 → 849
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01413
    Location:1464 → 1568
    C4; C-terminal tandem repeated domain in type 4 procollagen

  4. XM_038434527.1 → XP_038290455.1  collagen alpha-4(IV) chain isoform X3

    Conserved Domains (1) summary
    pfam01391
    Location:795 → 849
    Collagen; Collagen triple helix repeat (20 copies)

RNA

  1. XR_005301332.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    40038958..40143270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    39873785..39983389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    40052828..40157117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    40472320..40576418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.