U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HRH2 histamine receptor H2 [ Canis lupus familiaris (dog) ]

Gene ID: 403812, updated on 27-Jun-2026
Official Symbol
HRH2provided by VGNC
Official Full Name
histamine receptor H2provided by VGNC
Primary source
VGNC:VGNC:41787
See related
Ensembl:ENSCAFG00845000310 RGD:12344820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
H2R; HH2R
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See HRH2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (37699668..37772370, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (37330979..37332058, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (38272467..38273546, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (37574680..37575759, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (37762745..37763824, complement)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene THO complex subunit 3 Neighboring gene complexin 2 Neighboring gene 40S ribosomal protein S11-like Neighboring gene uncharacterized LOC111095711 Neighboring gene U6 spliceosomal RNA

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade. Takahama H, et al. Basic Res Cardiol, 2010 Nov. PMID 20852875
  2. Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs. Asanuma H, et al. J Mol Cell Cardiol, 2006 May. PMID 16603184
  3. Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting. Fukushima Y, et al. Biochim Biophys Acta, 2001 Jun 20. PMID 11420116
  4. Molecular cloning of a gene encoding the histamine H2 receptor. Gantz I, et al. Proc Natl Acad Sci U S A, 1991 Jan 15. PMID 1703298, Free PMC Article
  5. Molecular basis for the interaction of histamine with the histamine H2 receptor. Gantz I, et al. J Biol Chem, 1992 Oct 15. PMID 1356984

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histamine H receptor blockade preserves cardiac systolic function in dogs with pacing-induced heart failure, even in the presence of beta-adrenergic receptor blockade.
    Title: A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade.
  2. histamine H(2) receptors have roles in anaerobic myocardial metabolism and in ischemia and reperfusion injury
    Title: Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
histamine H2 receptor
Names
gastric receptor I
histamine receptor subtype H2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195844.1 → NP_001182773.1  histamine H2 receptor

    See identical proteins and their annotated locations for NP_001182773.1

    Status: PROVISIONAL

    Source sequence(s)
    JAAUVH010000355
    UniProtKB/Swiss-Prot
    P17124
    UniProtKB/TrEMBL
    A0A8C0KGF2, A0A8I3MAL7
    Conserved Domains (2) summary
    cd14964
    Location:20 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 299
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    37699668..37772370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038662231.1 → XP_038518159.1  histamine H2 receptor isoform X6

    UniProtKB/Swiss-Prot
    P17124
    UniProtKB/TrEMBL
    A0A8C0KGF2, A0A8I3MAL7
    Related
    ENSCAFP00845000340.1, ENSCAFT00845000497.1
    Conserved Domains (2) summary
    cd14964
    Location:20 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 299
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_038662225.1 → XP_038518153.1  histamine H2 receptor isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:392 → 535
    PHA03247; large tegument protein UL36; Provisional
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_038662226.1 → XP_038518154.1  histamine H2 receptor isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:392 → 535
    PHA03247; large tegument protein UL36; Provisional
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_038662228.1 → XP_038518156.1  histamine H2 receptor isoform X3

    UniProtKB/TrEMBL
    A0A8I3MCA9, A0A8I3MF03
    Related
    ENSCAFP00845000347.1, ENSCAFT00845000506.1
    Conserved Domains (1) summary
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_038662227.1 → XP_038518155.1  histamine H2 receptor isoform X2

    UniProtKB/TrEMBL
    A0A8I3MCA9, A0A8I3MF06
    Related
    ENSCAFP00845000359.1, ENSCAFT00845000522.1
    Conserved Domains (1) summary
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_038662230.1 → XP_038518158.1  histamine H2 receptor isoform X5

    UniProtKB/TrEMBL
    A0A8I3MAL7
    Conserved Domains (2) summary
    cd14964
    Location:20 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 299
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. XM_038662229.1 → XP_038518157.1  histamine H2 receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I3MAL7
    Conserved Domains (2) summary
    cd14964
    Location:20 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 299
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_005425096.1 RNA Sequence

  2. XR_005425097.1 RNA Sequence

  3. XR_005425098.1 RNA Sequence

  4. XR_005425099.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    37574680..37575759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    37762745..37763824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    38272467..38273546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37330979..37332058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17124.1 GenPept UniProtKB/Swiss-Prot:P17124

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous