IFNG interferon gamma [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IFNGprovided by VGNC
Official Full Name: interferon gammaprovided by VGNC
Primary source: VGNC:VGNC:41879
See related: Ensembl:ENSCAFG00845013680
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: IFN-G; IFN-gamma
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	10	NC_051814.1 (10530420..10535258, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	10	NC_006592.4 (10340127..10344948, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	10	NC_049231.1 (10768058..10772882, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	10	NC_049270.1 (10399244..10404067, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	10	NC_049751.1 (10645481..10650291, complement)
105	previous assembly	CanFam3.1 (GCF_000002285.3)	10	NC_006592.3 (10406866..10411698, complement)

Chromosome 10 - NC_051814.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in interferon-gamma and neopterin in female dogs undergoing ovariohysterectomy as elective spay or as treatment of pyometra.
Title: Changes in interferon-gamma and neopterin in female dogs undergoing ovariohysterectomy as elective spay or as treatment of pyometra.
IL-17A gene transcription level was positively correlated with mRNA expression for iNOS and IFN-gamma
Title: Impairment of Interleukin-17A Expression in Canine Visceral Leishmaniosis is Correlated with Reduced Interferon-γ and Inducible Nitric Oxide Synthase Expression.
In dogs with leishmaniasis, there was high expression of interferon gamma in lymph nodes.
Title: Cytokine gene expression in the tissues of dogs infected by Leishmania infantum.
These findings suggest that polyunsaturated fatty acids are able to influence proliferation of peripheral blood mononuclear cells in healthy and atopic dogs but do not seem to influence cytokine transcription.
Title: Effects of polyunsaturated fatty acids on isolated canine peripheral blood mononuclear cells and cytokine expression (IL-4, IFN-gamma, TGF-beta) in healthy and atopic dogs.

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General gene information

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Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables type II interferon receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in astrocyte activation	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tau-protein kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcidiol 1-monooxygenase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of core promoter binding	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fructose 1,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-23 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron death	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein deacetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vitamin D biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in type III interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.