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IL18 interleukin 18 [ Canis lupus familiaris (dog) ]

Gene ID: 403796, updated on 25-Jul-2026
Official Symbol
IL18provided by VGNC
Official Full Name
interleukin 18provided by VGNC
Primary source
VGNC:VGNC:41951
See related
Ensembl:ENSCAFG00845001557 RGD:12116574
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
IGIF
Orthologs
all
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Try the new Transcripts and proteins table
See IL18 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (20994967..21017974)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (20907590..20917853)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (21018633..21028888)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (21069981..21080260)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (20970245..20980530)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene 6-pyruvoyltetrahydropterin synthase Neighboring gene beta-carotene oxygenase 2 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene translocase of inner mitochondrial membrane 8 homolog B Neighboring gene NKAP domain containing 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning, sequencing, and characterization of dog interleukin-18. Argyle DJ, et al. Immunogenetics, 1999 Jun. PMID 10380699
  2. Cloning of cDNA for canine interleukin-18 and canine interleukin-1beta converting enzyme and expression of canine interleukin-18. Okano F, et al. J Interferon Cytokine Res, 1999 Jan. PMID 10048765
  3. Canine interleukin-18 induces apoptosis and enhances Fas ligand mRNA expression in a canine carcinoma cell line. Okano F, et al. Anticancer Res, 2000 Sep-Oct. PMID 11131641
  4. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Micallef MJ, et al. Eur J Immunol, 1996 Jul. PMID 8766574
  5. Semi-quantitative analysis of multiple cytokines in canine peripheral blood mononuclear cells by [correction of zby] a single tube RT-PCR. Chamizo C, et al. Vet Immunol Immunopathol, 2001 Dec. PMID 11730929

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interleukin-18
Names
IFN-gamma-inducing factor
IL-1 gamma
IL-18
interferon gamma-inducing factor
interleukin 18 (interferon-gamma-inducing factor)
interleukin-1 gamma

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003169.1 → NP_001003169.1  interleukin-18 precursor

    See identical proteins and their annotated locations for NP_001003169.1

    Status: PROVISIONAL

    Source sequence(s)
    Y11133
    UniProtKB/Swiss-Prot
    Q9XSR0
    UniProtKB/TrEMBL
    A0A8C0QW11
    Conserved Domains (1) summary
    cl00094
    Location:78 → 179
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    20994967..21017974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664074.1 → XP_038520002.1  interleukin-18 isoform X1

    UniProtKB/TrEMBL
    A0A8C0QW11, A0A8I3RRK2
    Related
    ENSCAFP00845002124.1, ENSCAFT00845002682.1
    Conserved Domains (1) summary
    cl00094
    Location:85 → 197
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

  2. XM_038664075.1 → XP_038520003.1  interleukin-18 isoform X2

    UniProtKB/TrEMBL
    A0A8C0QW11, A0A8I3ME31
    Related
    ENSCAFP00845002139.1, ENSCAFT00845002702.1
    Conserved Domains (1) summary
    cl00094
    Location:73 → 185
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    21069981..21080260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    20970245..20980530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    21018633..21028888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    20907590..20917853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XSR0.1 GenPept UniProtKB/Swiss-Prot:Q9XSR0

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