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NOS3 nitric oxide synthase 3 [ Canis lupus familiaris (dog) ]

Gene ID: 403784, updated on 17-Aug-2024

Summary

Official Symbol
NOS3provided by VGNC
Official Full Name
nitric oxide synthase 3provided by VGNC
Primary source
VGNC:VGNC:43896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
NOS
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See NOS3 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (16776276..16794533)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (15662484..15680572)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (15781028..15799144)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (15148899..15166990)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (15730292..15748445)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene amine oxidase copper containing 1 Neighboring gene uncharacterized LOC111090252 Neighboring gene potassium voltage-gated channel subfamily H member 2 Neighboring gene autophagy related 9B Neighboring gene ATP binding cassette subfamily B member 8 Neighboring gene acid sensing ion channel subunit 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
nitric oxide synthase 3
Names
EC-NOS
NOS type III
NOSIII
cNOS
constitutive NOS
eNOS
endothelial NOS
nitric oxide synthase, endothelial
NP_001003158.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003158.2NP_001003158.2  nitric oxide synthase 3

    Status: VALIDATED

    Source sequence(s)
    AAEX03010272
    UniProtKB/TrEMBL
    A0A8C0K110, A0A8C0PGE2, A0A8C0Q3E0
    Conserved Domains (3) summary
    cd00795
    Location:70482
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:524700
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:7641166
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    16776276..16794533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    15148899..15166990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    15730292..15748445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    15781028..15799144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    15662484..15680572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)