TJP1 tight junction protein 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TJP1provided by VGNC
Official Full Name: tight junction protein 1provided by VGNC
Primary source: VGNC:VGNC:47386
See related: Ensembl:ENSCAFG00845000384 RGD:12052585
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: ZO1; ZO-1
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	3	NC_051807.1 (39375018..39624615, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	3	NC_006585.4 (41683799..41794039, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	3	NC_049224.1 (39363904..39474165, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	3	NC_049263.1 (38917559..39028158, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	3	NC_049744.1 (39155559..39266003, complement)

Chromosome 3 - NC_051807.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network.
Title: ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network.
Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.
Title: Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.
In the present study, organspecific expression of the tight junction proteins, claudin, occludin, junction adhesion molecule A and zona occludens 1 was examined in the canine duodenum, lung, liver and kidney.
Title: Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
Occludin and ZO-1 expression remained unchanged between atopic and clinically normal dogs.
Title: Tight junction proteins in the canine epidermis: a pilot study on their distribution in normal and in high IgE-producing canines.
ZO-1 knockout induced striking changes in myosin organization at cell-cell contacts and disrupted the localization of tight junction proteins.
Title: ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape.
Akt-dependent phosphorylation of Serine 373 increases gap junction size and communication by completely eliminating the interaction between Cx43 and ZO-1.
Title: Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size.
our study identifies alpha-catenin binding to ZO-1 as a new mechanism for coupling the assembly of the epithelial barrier to cell-to-cell adhesion.
Title: ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions.
ZO-1 and ZO-2 proteins are required not only for TJ assembly but also for regulating the organization and functional activity of the apical cytoskeleton, particularly the perijunctional actomyosin ring; these activities are relevant both to cellular organization and epithelial morphogenesis.
Title: Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia.
CPEB-mediated zonal occludens-1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity
Title: CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity.
ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively
Title: A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EST10C1 (e-PCR)
- UniSTS:263026

TJP1 (e-PCR)
- UniSTS:479948

TJP1 (e-PCR)
- UniSTS:266199

EST651 (e-PCR)
- UniSTS:164060

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell junction organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment of endothelial intestinal barrier	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of blood-brain barrier permeability	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein localization to cell-cell junction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tight junction protein 1

Names: tight junction protein ZO-1; tight junction protein 1 (zona occludens 1); zonula occludens protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003140.1 → NP_001003140.1 tight junction protein 1

See identical proteins and their annotated locations for NP_001003140.1

Status: PROVISIONAL

Source sequence(s)

U55935

UniProtKB/Swiss-Prot

O97758

UniProtKB/TrEMBL

A0A8C0LIP0

Related

ENSCAFP00845000577.1, ENSCAFT00845000780.1

Conserved Domains (6) summary

cd12026
Location:516 → 580

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:614 → 793

GuKc; Guanylate kinase homologues

smart00228
Location:182 → 262

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:424 → 500

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1635 → 1733

ZU5; ZU5 domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051807.1 Reference ROS_Cfam_1.0

Range

39375018..39624615 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038660427.1 → XP_038516355.1 tight junction protein ZO-1 isoform X4

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (8) summary

smart00218
Location:1743 → 1849

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1392 → 1695

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1166 → 1297

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_038660425.1 → XP_038516353.1 tight junction protein ZO-1 isoform X2

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (8) summary

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1392 → 1695

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1166 → 1297

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1746 → 1835

ZU5; ZU5 domain
XM_038660442.1 → XP_038516370.1 tight junction protein ZO-1 isoform X14

UniProtKB/TrEMBL

A0A8C0LCJ5

Conserved Domains (7) summary

smart00218
Location:1646 → 1752

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1107 → 1504

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_038660436.1 → XP_038516364.1 tight junction protein ZO-1 isoform X12

UniProtKB/TrEMBL

A0A8C0LCJ5

Related

ENSCAFP00845000515.1, ENSCAFT00845000707.1

Conserved Domains (7) summary

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1107 → 1504

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1649 → 1748

ZU5; ZU5 domain
XM_038660433.1 → XP_038516361.1 tight junction protein ZO-1 isoform X10

UniProtKB/TrEMBL

A0A8C0LCJ5

Conserved Domains (8) summary

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1312 → 1615

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1086 → 1217

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1666 → 1765

ZU5; ZU5 domain
XM_038660432.1 → XP_038516360.1 tight junction protein ZO-1 isoform X9

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK10263
Location:1166 → 1297

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1684 → 1783

ZU5; ZU5 domain
XM_038660429.1 → XP_038516357.1 tight junction protein ZO-1 isoform X6

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

smart00218
Location:1726 → 1832

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1187 → 1584

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_038660428.1 → XP_038516356.1 tight junction protein ZO-1 isoform X5

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1187 → 1584

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1729 → 1818

ZU5; ZU5 domain
XM_038660426.1 → XP_038516354.1 tight junction protein ZO-1 isoform X3

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1187 → 1584

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1729 → 1828

ZU5; ZU5 domain
XM_038660431.1 → XP_038516359.1 tight junction protein ZO-1 isoform X8

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK10263
Location:1166 → 1297

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1701 → 1800

ZU5; ZU5 domain
XM_038660424.1 → XP_038516352.1 tight junction protein ZO-1 isoform X1

UniProtKB/TrEMBL

A0A8I3MAQ1, A0A8I3MFM5

Related

ENSCAFP00845000444.1, ENSCAFT00845000632.1

Conserved Domains (8) summary

cd12026
Location:609 → 673

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:275 → 355

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1392 → 1695

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1166 → 1297

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:517 → 593

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1746 → 1845

ZU5; ZU5 domain
XM_038660438.1 → XP_038516366.1 tight junction protein ZO-1 isoform X13

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:504 → 568

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:602 → 781

GuKc; Guanylate kinase homologues

smart00228
Location:170 → 250

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1287 → 1590

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:10 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:412 → 488

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1641 → 1740

ZU5; ZU5 domain
XM_038660439.1 → XP_038516367.1 tight junction protein ZO-1 isoform X13

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:504 → 568

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:602 → 781

GuKc; Guanylate kinase homologues

smart00228
Location:170 → 250

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1287 → 1590

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:10 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:412 → 488

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1641 → 1740

ZU5; ZU5 domain
XM_038660437.1 → XP_038516365.1 tight junction protein ZO-1 isoform X13

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:504 → 568

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:602 → 781

GuKc; Guanylate kinase homologues

smart00228
Location:170 → 250

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1287 → 1590

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:10 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:412 → 488

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1641 → 1740

ZU5; ZU5 domain
XM_038660430.1 → XP_038516358.1 tight junction protein ZO-1 isoform X7

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (8) summary

cd12026
Location:566 → 630

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:664 → 843

GuKc; Guanylate kinase homologues

smart00228
Location:232 → 312

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1349 → 1652

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:1123 → 1254

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:72 → 157

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:474 → 550

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1703 → 1802

ZU5; ZU5 domain
XM_038660441.1 → XP_038516369.1 tight junction protein ZO-1 isoform X13

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:504 → 568

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:602 → 781

GuKc; Guanylate kinase homologues

smart00228
Location:170 → 250

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1287 → 1590

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:10 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:412 → 488

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1641 → 1740

ZU5; ZU5 domain
XM_038660440.1 → XP_038516368.1 tight junction protein ZO-1 isoform X13

UniProtKB/TrEMBL

A0A8I3MFM5

Conserved Domains (7) summary

cd12026
Location:504 → 568

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:602 → 781

GuKc; Guanylate kinase homologues

smart00228
Location:170 → 250

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1287 → 1590

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:10 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:412 → 488

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1641 → 1740

ZU5; ZU5 domain
XM_038660434.1 → XP_038516362.1 tight junction protein ZO-1 isoform X11

UniProtKB/TrEMBL

A0A8I3MFM5, A0A8I3MHW2

Related

ENSCAFP00845000543.1, ENSCAFT00845000741.1

Conserved Domains (7) summary

cd12026
Location:516 → 580

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:614 → 793

GuKc; Guanylate kinase homologues

smart00228
Location:182 → 262

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1299 → 1602

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:424 → 500

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1653 → 1752

ZU5; ZU5 domain