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MMP2 matrix metallopeptidase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 403733, updated on 1-Mar-2025

Summary

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Official Symbol
MMP2provided by VGNC
Official Full Name
matrix metallopeptidase 2provided by VGNC
Primary source
VGNC:VGNC:43280
See related
Ensembl:ENSCAFG00845000865 RGD:12057161
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
MMP-2
Orthologs
human mouse all
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Genomic context

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See MMP2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (61016206..61041216, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (57105772..57130788, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (59747357..59772363, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (57844808..57869825, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (58869067..58894067, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 2 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain small subunit 2 Neighboring gene L-xylulose reductase-like Neighboring gene uncharacterized LOC102154386

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Marked MMP-2 transcriptional up-regulation in mononuclear leukocytes invading the subarachnoidal space in aseptic suppurative steroid-responsive meningitis-arteritis in dogs. Schwartz M, et al. Vet Immunol Immunopathol, 2010 Feb 15. PMID 19733404
  2. MMP-2 as an early synovial biomarker for cranial cruciate ligament disease in dogs. Boland L, et al. Vet Comp Orthop Traumatol, 2014. PMID 24664192
  3. Immunohistochemical assessment of metalloproteinases MMP2 and MMP9 expression in canine various subtypes of lymphomas in relation with proliferative and apoptotic markers. Sokołowska J, et al. Pol J Vet Sci, 2019 Jun. PMID 31269334
  4. Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ). Fukushima K, et al. BMC Musculoskelet Disord, 2007 Jun 28. PMID 17598883, Free PMC Article
  5. The cloning and expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma. Newman RG, et al. Res Vet Sci, 2008 Apr. PMID 17604063

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results were not able to clearly confirm the influence of MMPs on the proliferation and apoptotic activity of canine lymphoma cells.
    Title: Immunohistochemical assessment of metalloproteinases MMP2 and MMP9 expression in canine various subtypes of lymphomas in relation with proliferative and apoptotic markers.
  2. The parasite load, intensity of inflammation, and production of MMP-2 (latent) and MMP-9 (active and latent) were higher in the ear and muzzle regions.
    Title: Expression of matrix metalloproteinase-2 and metalloproteinase-9 in the skin of dogs with visceral leishmaniasis.
  3. MMP-2 and MMP-9 expression extended to the implantative endometrium, including deep glandular areas. enzymatic activity in the labyrinth, the implantative endometrium and the marginal haematoma was limited to MMP-2.
    Title: Differential expression and activity of matrix metalloproteinases 2 and 9 in canine early placenta.
  4. expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 was found in canine transmissible venereal tumors
    Title: Immunocharacterization of matrix metalloproteinase-2 and matrix metalloproteinase-9 in canine transmissible venereal tumors.
  5. Suggest cryoplasty increases the expression of TIMP-2 and decreases the expression of MMP-2, thereby inhibiting vascular hyperplasia and collagen fibers synthesis in the stenotic vessels.
    Title: Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2.
  6. the alteration of Cx43 and/or phosphorylated Cx43 levels and the imbalance of MMP-2 and TIMP-2 may contribute to the initiation and/or persistence of ventricular fibrillation.
    Title: Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine.
  7. This study confirmed that MMP-2 activity is significantly related to CrCL rupture, but there was a failure to demonstrate any significant increase in the contralateral joints compared to the stifle joints of normal dogs.
    Title: MMP-2 as an early synovial biomarker for cranial cruciate ligament disease in dogs.
  8. This study suggests that MMP-2 and MMP-9 may take part in the brain inflammatory changes of subacute distemper leukoencephalitis.
    Title: Zymographic patterns of MMP-2 and MMP-9 in the CSF and cerebellum of dogs with subacute distemper leukoencephalitis.
  9. These results suggested that remissive effect on liver fibrosis might be partly attributable to the MMP-2 and -9 activity in bone marrow stromal cells under the inflammatory condition.
    Title: Matrix metalloproteinases (MMPs) activity in cultured canine bone marrow stromal cells (BMSCs).
  10. MMP-9 was overexpressed in malignant melanomas, compared with expression in melanocytomas, whereas no significant differences in MMP-2 and MT1-MMP immunostaining were detected.
    Title: Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
72 kDa type IV collagenase
Names
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
matrix metalloproteinase-2
XP_038316879.1
XP_038326126.1
XP_038386948.1
XP_038451167.1
XP_038515255.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    61016206..61041216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038659327.1 → XP_038515255.1  72 kDa type IV collagenase

    UniProtKB/TrEMBL
    A0A8C0S3W7, A0A8I3MD29
    Related
    ENSCAFP00845001159.1, ENSCAFT00845001478.1
    Conserved Domains (4) summary
    smart00059
    Location:208 → 256
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390 → 584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:42 → 370
    Peptidase_M10; Matrixin
    pfam01471
    Location:1 → 21
    PG_binding_1; Putative peptidoglycan binding domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    57844808..57869825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038470198.1 → XP_038326126.1  72 kDa type IV collagenase

    Conserved Domains (4) summary
    smart00059
    Location:208 → 256
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390 → 584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:42 → 370
    Peptidase_M10; Matrixin
    pfam01471
    Location:1 → 21
    PG_binding_1; Putative peptidoglycan binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    58869067..58894067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038595239.1 → XP_038451167.1  72 kDa type IV collagenase

    Conserved Domains (4) summary
    smart00059
    Location:208 → 256
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390 → 584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:42 → 370
    Peptidase_M10; Matrixin
    pfam01471
    Location:1 → 21
    PG_binding_1; Putative peptidoglycan binding domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    59747357..59772363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038531020.1 → XP_038386948.1  72 kDa type IV collagenase

    UniProtKB/TrEMBL
    A0A8C0S3W7, A0A8I3MD29
    Conserved Domains (4) summary
    smart00059
    Location:208 → 256
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390 → 584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:42 → 370
    Peptidase_M10; Matrixin
    pfam01471
    Location:1 → 21
    PG_binding_1; Putative peptidoglycan binding domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    57105772..57130788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038460951.1 → XP_038316879.1  72 kDa type IV collagenase

    UniProtKB/TrEMBL
    A0A8C0S3W7, A0A8I3MD29
    Conserved Domains (4) summary
    smart00059
    Location:208 → 256
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390 → 584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:42 → 370
    Peptidase_M10; Matrixin
    pfam01471
    Location:1 → 21
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein
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