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CASP4 caspase 4, apoptosis-related cysteine peptidase [ Canis lupus familiaris (dog) ]

Gene ID: 403724, updated on 5-Sep-2025
Gene symbol
CASP4
Gene description
caspase 4, apoptosis-related cysteine peptidase
See related
Ensembl:ENSCAFG00845000375 RGD:12113986
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
CASP1; IL1BC
Annotation information
Annotation category: partial on reference assembly
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See CASP4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (27170519..27184696)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (27064601..27078777)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (27257464..27271644)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (27212077..27226245)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (27098364..27112532)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils Neighboring gene glutamate ionotropic receptor AMPA type subunit 4 Neighboring gene 60 kDa heat shock protein, mitochondrial-like Neighboring gene uncharacterized LOC119871825 Neighboring gene uncharacterized LOC106558805 Neighboring gene caspase 12 Neighboring gene 14-3-3 protein theta-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides. Taylor S, et al. DNA Seq, 2000. PMID 10826695
  2. Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire. Eckhart L, et al. Mol Biol Evol, 2008 May. PMID 18281271
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables caspase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
caspase-1
Names
CASP-1
ICE
IL-1 beta-converting enzyme
IL-1BC
caspase-1/caspase-4 hybrid
interleukin-1 beta convertase
interleukin-1 beta-converting enzyme
p45
NP_001003125.1

Length

  • 404

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003125.1 → NP_001003125.1  caspase-1

    See identical proteins and their annotated locations for NP_001003125.1

    Status: PROVISIONAL

    Source sequence(s)
    AF135967
    UniProtKB/Swiss-Prot
    Q9MZV7
    UniProtKB/TrEMBL
    A0A8C0MQW5
    Related
    ENSCAFP00845000456.1, ENSCAFT00845000645.1
    Conserved Domains (2) summary
    smart00115
    Location:153 → 402
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08325
    Location:5 → 87
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    27170519..27184696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    27212077..27226245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    27098364..27112532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    27257464..27271644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    27064601..27078777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MZV7.1 GenPept UniProtKB/Swiss-Prot:Q9MZV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials