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LRP3 LDL receptor related protein 3 [ Homo sapiens (human) ]

Gene ID: 4037, updated on 5-Aug-2018

Summary

Official Symbol
LRP3provided by HGNC
Official Full Name
LDL receptor related protein 3provided by HGNC
Primary source
HGNC:HGNC:6695
See related
Ensembl:ENSG00000130881 MIM:603159; Vega:OTTHUMG00000180343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 23.4), fat (RPKM 17.1) and 24 other tissues See more
Orthologs

Genomic context

See LRP3 in Genome Data Viewer
Location:
19q13.11
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (33194693..33208867)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33685599..33699773)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WD repeat domain 88 Neighboring gene transfer RNA-Thr (AGT) 1-3 Neighboring gene solute carrier family 7 member 10 Neighboring gene HNF1 motif-containing MPRA enhancer 13 Neighboring gene CCAAT enhancer binding protein alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
low-density lipoprotein receptor-related protein 3
Names
105 kDa low-density lipoprotein receptor-related protein
CTD-2540B15.13
LRP-3
hLRp105

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002333.3NP_002324.2  low-density lipoprotein receptor-related protein 3 precursor

    See identical proteins and their annotated locations for NP_002324.2

    Status: VALIDATED

    Source sequence(s)
    AB009462, AC008738, AK126750, BC007408, BU739456, DA496540
    Consensus CDS
    CCDS12430.1
    UniProtKB/Swiss-Prot
    O75074
    Related
    ENSP00000253193.6, OTTHUMP00000264030, ENST00000253193.8, OTTHUMT00000450842
    Conserved Domains (2) summary
    cd00041
    Location:43156
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:455489
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    33194693..33208867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258945.1XP_005259002.1  low-density lipoprotein receptor-related protein 3 isoform X1

    Conserved Domains (2) summary
    cd00041
    Location:43156
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:455489
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
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