NPC1 NPC intracellular cholesterol transporter 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NPC1provided by VGNC
Official Full Name: NPC intracellular cholesterol transporter 1provided by VGNC
Primary source: VGNC:VGNC:43913
See related: Ensembl:ENSCAFG00845014993 RGD:12435558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	7	NC_051811.1 (64809192..64861828)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	7	NC_006589.4 (64198337..64251229)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	7	NC_049228.1 (64797527..64850181)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	7	NC_049267.1 (64477149..64529713)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	7	NC_049748.1 (64492712..64545342)

Chromosome 7 - NC_051811.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables lipid carrier activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NPC intracellular cholesterol transporter 1

Names: Niemann-Pick type C1 disease protein

NP_001003107.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003107.2 → NP_001003107.2 NPC intracellular cholesterol transporter 1 precursor

Status: VALIDATED

Source sequence(s)

AF315034, BU749715, DN870418

UniProtKB/TrEMBL

A0A8I3NZ87

Related

ENSCAFP00845021127.1, ENSCAFT00845026829.1

Conserved Domains (1) summary

TIGR00917
Location:25 → 1250

2A060601; Niemann-Pick C type protein family