Format

Send to:

Choose Destination

EGF epidermal growth factor [ Canis lupus familiaris (dog) ]

Gene ID: 403657, updated on 17-Nov-2020

Summary

Official Symbol
EGFprovided by VGNC
Official Full Name
epidermal growth factorprovided by VGNC
Primary source
VGNC:VGNC:40235
See related
Ensembl:ENSCAFG00000011532
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
CEGF
Orthologs

Genomic context

See EGF in Genome Data Viewer
Location:
chromosome: 32
Exon count:
24
Annotation release Status Assembly Chr Location
105 current CanFam3.1 (GCF_000002285.3) 32 NC_006614.3 (30073541..30166904)

Chromosome 32 - NC_006614.3Genomic Context describing neighboring genes Neighboring gene retinal pigment epithelium-derived rhodopsin homolog Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 3 Neighboring gene 40S ribosomal protein S27-like Neighboring gene uncharacterized LOC111093671 Neighboring gene 60S ribosomal protein L30 pseudogene Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene uncharacterized LOC111093670 Neighboring gene ELOVL fatty acid elongase 6

Genomic regions, transcripts, and products

Genomic Sequence:
NC_006614.3 Chromosome 32 Reference CanFam3.1 Primary Assembly

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
epidermal growth factor receptor signaling pathway via MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pro-epidermal growth factor
Names
epidermal growth factor (beta-urogastrone)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003094.1NP_001003094.1  pro-epidermal growth factor precursor

    See identical proteins and their annotated locations for NP_001003094.1

    Status: PROVISIONAL

    Source sequence(s)
    AB049597
    UniProtKB/Swiss-Prot
    Q9BEA0
    Related
    ENSCAFP00000016954.4, ENSCAFT00000018307.4
    Conserved Domains (7) summary
    PHA02887
    Location:9751015
    PHA02887; EGF-like protein; Provisional
    smart00135
    Location:637678
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:873913
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:915943
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam12662
    Location:338361
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:747782
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:353395
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

  1. NC_006614.3 Reference CanFam3.1 Primary Assembly

    Range
    30073541..30166904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014109884.2XP_013965359.1  pro-epidermal growth factor isoform X1

    UniProtKB/TrEMBL
    J9NZ75
    Conserved Domains (7) summary
    PHA02887
    Location:9751015
    PHA02887; EGF-like protein; Provisional
    smart00135
    Location:637678
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:873913
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:915943
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam12662
    Location:338361
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:747782
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:353395
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. XM_022413384.1XP_022269092.1  pro-epidermal growth factor isoform X2

    Conserved Domains (7) summary
    smart00135
    Location:637678
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:832872
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:874902
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam12662
    Location:338361
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:747782
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:353395
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl28647
    Location:934974
    PHA02887; EGF-like protein; Provisional
Support Center