PPARA peroxisome proliferator activated receptor alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PPARAprovided by VGNC
Official Full Name: peroxisome proliferator activated receptor alphaprovided by VGNC
Primary source: VGNC:VGNC:44834
See related: Ensembl:ENSCAFG00845010405
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	10	NC_051814.1 (20667818..20740885, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	10	NC_006592.4 (19862969..19928467, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	10	NC_049231.1 (20889156..20954630, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	10	NC_049270.1 (20394544..20460174, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	10	NC_049751.1 (20707323..20772988, complement)

Chromosome 10 - NC_051814.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fenofibrate promotes PPARalpha-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus.
Title: Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus.
PPARs were therefore induced in canine testicular tumours and they may play a role in the biology of these tumours.
Title: Immunohistochemical characterization of peroxisome proliferator-activated receptors in canine normal testis and testicular tumours.
Simvastatin, pravastatin, and NO-pravastatin increased expression of the proteins PPARalpha, PPARgamma, and ABCA1, and expression of the mRNA of ABCA1 and LXRalpha in GBEC.
Title: HMG-CoA reductase inhibitors (statins) activate expression of PPARalpha/PPARgamma and ABCA1 in cultured gallbladder epithelial cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: peroxisome proliferator-activated receptor alpha

Names: PPAR alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003093.1 → NP_001003093.1 peroxisome proliferator-activated receptor alpha

See identical proteins and their annotated locations for NP_001003093.1

Status: PROVISIONAL

Source sequence(s)

AF350327

UniProtKB/Swiss-Prot

Q95N78

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051814.1 Reference ROS_Cfam_1.0

Range

20667818..20740885 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038678755.1 → XP_038534683.1 peroxisome proliferator-activated receptor alpha isoform X3

Related

ENSCAFP00845014355.1, ENSCAFT00845018388.1

Conserved Domains (2) summary

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

cl11397
Location:216 → 401

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_038678752.1 → XP_038534680.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/TrEMBL

A0A8C0K8L0, A0A8C0S114, A0A8I3N5V2

Conserved Domains (2) summary

cd06932
Location:216 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_038678757.1 → XP_038534685.1 peroxisome proliferator-activated receptor alpha isoform X2

UniProtKB/Swiss-Prot

Q95N78

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_038678756.1 → XP_038534684.1 peroxisome proliferator-activated receptor alpha isoform X2

UniProtKB/Swiss-Prot

Q95N78

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_038678753.1 → XP_038534681.1 peroxisome proliferator-activated receptor alpha isoform X2

UniProtKB/Swiss-Prot

Q95N78

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_038678749.1 → XP_038534677.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/TrEMBL

A0A8C0K8L0, A0A8C0S114, A0A8I3N5V2

Conserved Domains (2) summary

cd06932
Location:216 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_038678750.1 → XP_038534678.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/TrEMBL

A0A8C0K8L0, A0A8C0S114, A0A8I3N5V2

Conserved Domains (2) summary

cd06932
Location:216 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_038678754.1 → XP_038534682.1 peroxisome proliferator-activated receptor alpha isoform X2

UniProtKB/Swiss-Prot

Q95N78

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_038678751.1 → XP_038534679.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/TrEMBL

A0A8C0K8L0, A0A8C0S114, A0A8I3N5V2

Related

ENSCAFP00845014438.1, ENSCAFT00845018508.1

Conserved Domains (2) summary

cd06932
Location:216 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers