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ESR1 estrogen receptor 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403640, updated on 17-Aug-2024

Summary

Official Symbol
ESR1provided by VGNC
Official Full Name
estrogen receptor 1provided by VGNC
Primary source
VGNC:VGNC:40476
See related
Ensembl:ENSCAFG00845000028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
ERALPHA
Orthologs
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Genomic context

See ESR1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (42267417..42551842)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (42923315..43207109)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (42491321..42775607)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (42140418..42417150)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (41990600..42280338)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095762 Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC119870753 Neighboring gene uncharacterized LOC102151483 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene MYC target 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286958.2NP_001273887.1  estrogen receptor

    See identical proteins and their annotated locations for NP_001273887.1

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000354
    UniProtKB/TrEMBL
    A0A8C0KQE4, A0A8C0SV34, A0A8I3MAV6
    Related
    ENSCAFP00845000028.1, ENSCAFT00845000042.1
    Conserved Domains (4) summary
    cd06949
    Location:311548
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:181262
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:40182
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:557596
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    42267417..42551842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653376.1XP_038509304.1  estrogen receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0KS07
    Conserved Domains (3) summary
    cd07171
    Location:181264
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:40182
    Oest_recep; Oestrogen receptor
    cl11397
    Location:313463
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. XM_038653375.1XP_038509303.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A0A8C0KQE4, A0A8C0SV34, A0A8I3MAV6
    Conserved Domains (4) summary
    cd06949
    Location:313550
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:181264
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:40182
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:559598
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    42140418..42417150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    41990600..42280338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    42491321..42775607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42923315..43207109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)