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ESR1 estrogen receptor 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403640, updated on 17-Aug-2024

Summary

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Official Symbol
ESR1provided by VGNC
Official Full Name
estrogen receptor 1provided by VGNC
Primary source
VGNC:VGNC:40476
See related
Ensembl:ENSCAFG00845000028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
ERALPHA
Orthologs
human mouse all
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Genomic context

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See ESR1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (42267417..42551842)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (42923315..43207109)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (42491321..42775607)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (42140418..42417150)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (41990600..42280338)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095762 Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC119870753 Neighboring gene uncharacterized LOC102151483 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene MYC target 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Estrogen receptors genotypes and canine mammary neoplasia. Canadas-Sousa A, et al. BMC Vet Res, 2019 Sep 10. PMID 31506083, Free PMC Article
  2. The ESR1 gene is associated with risk for canine mammary tumours. Borge KS, et al. BMC Vet Res, 2013 Apr 10. PMID 23574728, Free PMC Article
  3. Homozygosity of single nucleotide polymorphisms in the 3' region of the canine estrogen receptor 1 gene is greater in Toy Poodles than in Miniature Dachshunds and Chihuahuas. Pathirana IN, et al. Anim Sci J, 2011 Jun. PMID 21615831
  4. Analysis of single nucleotide polymorphisms in the 3' region of the estrogen receptor 1 gene in normal and cryptorchid Miniature Dachshunds and Chihuahuas. Pathirana IN, et al. J Reprod Dev, 2010 Aug. PMID 20453437
  5. ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells. Colitz CM, et al. Mol Vis, 2009 Nov 9. PMID 19936027, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p53, ER, and Ki67 Expression in Canine Mammary Carcinomas and Correlation With Pathological Variables and Prognosis.
    Title: p53, ER, and Ki67 Expression in Canine Mammary Carcinomas and Correlation With Pathological Variables and Prognosis.
  2. the association between seven single nucleotide polymorphisms (SNPs) in canine ESR1 gene and clinicopathological features of canine mammary tumors and the clinical outcome of the disease
    Title: Estrogen receptors genotypes and canine mammary neoplasia.
  3. We concluded that sex steroid receptors and apoptotic proteins are differentially expressed in the follicles of adult dogs with polystic ovaries
    Title: Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs.
  4. associated with risk for mammary tumours
    Title: The ESR1 gene is associated with risk for canine mammary tumours.
  5. These results imply that homozygosity for the allele, genotype and haplotype distribution within the block at the 3' end of ESR1 is greater in Toy Poodles than in Miniature Dachshunds and Chihuahuas.
    Title: Homozygosity of single nucleotide polymorphisms in the 3' region of the canine estrogen receptor 1 gene is greater in Toy Poodles than in Miniature Dachshunds and Chihuahuas.
  6. Analysis of SNPs in 3'region of esr1 in cryptorchid dogs.
    Title: Analysis of single nucleotide polymorphisms in the 3' region of the estrogen receptor 1 gene in normal and cryptorchid Miniature Dachshunds and Chihuahuas.
  7. TERT interacted with ERalpha via the estrogen response element (ERE) in cataractous lens epithelial cells (LEC) but not in normal LEC.
    Title: ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells.
  8. A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.
    Title: A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
estrogen receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286958.2 → NP_001273887.1  estrogen receptor

    See identical proteins and their annotated locations for NP_001273887.1

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000354
    UniProtKB/TrEMBL
    A0A8C0KQE4, A0A8C0SV34, A0A8I3MAV6
    Related
    ENSCAFP00845000028.1, ENSCAFT00845000042.1
    Conserved Domains (4) summary
    cd06949
    Location:311 → 548
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:181 → 262
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:40 → 182
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:557 → 596
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    42267417..42551842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653376.1 → XP_038509304.1  estrogen receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0KS07
    Conserved Domains (3) summary
    cd07171
    Location:181 → 264
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:40 → 182
    Oest_recep; Oestrogen receptor
    cl11397
    Location:313 → 463
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  2. XM_038653375.1 → XP_038509303.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A0A8C0KQE4, A0A8C0SV34, A0A8I3MAV6
    Conserved Domains (4) summary
    cd06949
    Location:313 → 550
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:181 → 264
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:40 → 182
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:559 → 598
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    42140418..42417150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    41990600..42280338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    42491321..42775607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42923315..43207109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Research Materials