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BCL2L1 BCL2 like 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403618, updated on 5-Mar-2024

Summary

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Official Symbol
BCL2L1provided by VGNC
Official Full Name
BCL2 like 1provided by VGNC
Primary source
VGNC:VGNC:38408
See related
Ensembl:ENSCAFG00845018778
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
BCL-XL
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (21828012..21896118, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (20792367..20843516, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (21645527..21696882, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (21109822..21160959, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (21214910..21266211, complement)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene inhibitor of DNA binding 1 Neighboring gene uncharacterized LOC106557730 Neighboring gene cytochrome c oxidase subunit 4I2 Neighboring gene TPX2 microtubule nucleation factor Neighboring gene myosin light chain kinase 2 Neighboring gene forkhead box S1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Role of Bcl-xL Protein Research in Veterinary Oncology. Pawlak A, et al. Int J Mol Sci, 2020 Apr 4. PMID 32260403, Free PMC Article
  2. [Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy]. Sang Y, et al. Zhonghua Xin Xue Guan Bing Za Zhi, 2011 May. PMID 21781600

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of Bcl-xL Protein Research in Veterinary Oncology.
    Title: The Role of Bcl-xL Protein Research in Veterinary Oncology.
  2. Valsartan and carnitine could reduce alcoholic cardiomyopathy by downregulating Calpain-1 and Bad protein expression and upregulating expression of Bcl-xl protein.
    Title: [Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy].
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bcl-2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003072.1 → NP_001003072.1  bcl-2-like protein 1

    See identical proteins and their annotated locations for NP_001003072.1

    Status: PROVISIONAL

    Source sequence(s)
    AB073983
    UniProtKB/TrEMBL
    A0A8C0JVF6, A0A8C0TGM4, Q76LT7
    Conserved Domains (1) summary
    TIGR00865
    Location:1 → 233
    bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    21828012..21896118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432797.1 → XP_038288725.1  bcl-2-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVF6, A0A8C0TGM4, Q76LT7
    Conserved Domains (1) summary
    TIGR00865
    Location:1 → 233
    bcl-2; apoptosis regulator

  2. XM_038432796.1 → XP_038288724.1  bcl-2-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVF6, A0A8C0TGM4, Q76LT7
    Related
    ENSCAFP00845025973.1, ENSCAFT00845033178.1
    Conserved Domains (1) summary
    TIGR00865
    Location:1 → 233
    bcl-2; apoptosis regulator

  3. XM_038432795.1 → XP_038288723.1  bcl-2-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVF6, A0A8C0TGM4, Q76LT7
    Conserved Domains (1) summary
    TIGR00865
    Location:1 → 233
    bcl-2; apoptosis regulator

  4. XM_038432794.1 → XP_038288722.1  bcl-2-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVF6, A0A8C0TGM4, Q76LT7
    Conserved Domains (1) summary
    TIGR00865
    Location:1 → 233
    bcl-2; apoptosis regulator

  5. XM_038432793.1 → XP_038288721.1  bcl-2-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVF6, A0A8C0TGM4, Q76LT7
    Conserved Domains (1) summary
    TIGR00865
    Location:1 → 233
    bcl-2; apoptosis regulator

  6. XM_038432792.1 → XP_038288720.1  bcl-2-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVF6, A0A8C0TGM4, Q76LT7
    Conserved Domains (1) summary
    TIGR00865
    Location:1 → 233
    bcl-2; apoptosis regulator

  7. XM_038432798.1 → XP_038288726.1  bcl-2-like protein 1 isoform X2

    Conserved Domains (1) summary
    TIGR00865
    Location:1 → 189
    bcl-2; apoptosis regulator

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    21109822..21160959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    21214910..21266211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    21645527..21696882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    20792367..20843516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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