PLG plasminogen [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PLGprovided by VGNC
Official Full Name: plasminogenprovided by VGNC
Primary source: VGNC:VGNC:110549
See related: Ensembl:ENSCAFG00845002222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (49682496..49720525, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (50340229..50378262, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (50051672..50089725, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (49564853..49602878, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (49436580..49474619, complement)
105	previous assembly	CanFam3.1 (GCF_000002285.3)	1	NC_006583.3 (49497229..49535260, complement)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutation in PLG is associated with ligneous membranitis in Scottish Terriers
Title: Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene.
The critical condition for forming stable complexes of streptococcal enolase with canine plasminogen involves Str enolase binding to a surface.
Title: The interaction of streptococcal enolase with canine plasminogen: the role of surfaces in complex formation.
This work examines the interaction between canine plasminogen (dPgn) and Streptococcus pyogenes enolase (Str enolase).
Title: The interaction of canine plasminogen with Streptococcus pyogenes enolase: they bind to one another but what is the nature of the structures involved?
Plasmin activates epithelial Na+ channels by cleaving the gamma subunit
Title: Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.
Temperature changes induce large structural changes, as though the packing density of the protein increases as the temperature is raised
Title: Influence of temperature on the conformation of canine plasminogen: an analytical ultracentrifugation and dynamic light scattering study.

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General gene information

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Homology

Homologs of the PLG gene: The PLG gene is conserved in human, chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 416 organisms have orthologs with human gene PLG
Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in tissue remodeling	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plasminogen

NP_001273889.1

EC 3.4.21.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286960.1 → NP_001273889.1 plasminogen precursor

Status: VALIDATED

Source sequence(s)

JAAUVH010000354

UniProtKB/TrEMBL

A0A8C0N481, A0A8I3MF27, F1Q421

Related

ENSCAFP00845003117.1, ENSCAFT00845003910.1

Conserved Domains (3) summary

smart00130
Location:183 → 262

KR; Kringle domain

smart00473
Location:59 → 97

PAN_AP; divergent subfamily of APPLE domains

cd00190
Location:583 → 808

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...