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UCP2 uncoupling protein 2 [ Canis lupus familiaris (dog) ]

Gene ID: 403576, updated on 27-Jun-2026
Official Symbol
UCP2provided by VGNC
Official Full Name
uncoupling protein 2provided by VGNC
Primary source
VGNC:VGNC:48111
See related
Ensembl:ENSCAFG00845007207 RGD:12229421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See UCP2 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (24510583..24517796)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (24075387..24078118)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (24425514..24428245)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (24310265..24312996)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (24510181..24512912)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene uncoupling protein 3 Neighboring gene protein FAM91A1-like Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene uncharacterized LOC119864978 Neighboring gene tetraspanin-3-like Neighboring gene proteasomal ATPase associated factor 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Role of Uncoupling Protein 2 During Myocardial Dysfunction in a Canine Model of Endotoxin Shock. Wang X, et al. Shock, 2015 Mar. PMID 25526378
  2. Canine mitochondrial uncoupling proteins: structure and mRNA expression of three isoforms in adult beagles. Ishioka K, et al. Comp Biochem Physiol B Biochem Mol Biol, 2002 Mar. PMID 11959030
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UCP2 protein and mRNA levels were negatively correlated with myocardial energy levels in a model of endotoxic shock
    Title: The Role of Uncoupling Protein 2 During Myocardial Dysfunction in a Canine Model of Endotoxin Shock.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables oxidative phosphorylation uncoupler activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive thermogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrial transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrial transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
dicarboxylate carrier UCP2
Names
mitochondrial uncoupling protein 2
UCP 2
dicarboxylate carrier SLC25A8
solute carrier family 25 member 8

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003048.1 → NP_001003048.1  dicarboxylate carrier UCP2

    See identical proteins and their annotated locations for NP_001003048.1

    Status: PROVISIONAL

    Source sequence(s)
    AB020887
    UniProtKB/Swiss-Prot
    Q9N2J1, Q9TTT0
    Conserved Domains (2) summary
    PTZ00169
    Location:17 → 299
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:112 → 206
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    24510583..24517796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038429438.1 → XP_038285366.1  mitochondrial uncoupling protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JML0, F1PWF8, F8WQU7
    Related
    ENSCAFP00845009964.1, ENSCAFT00845012776.1
    Conserved Domains (1) summary
    pfam00153
    Location:112 → 206
    Mito_carr; Mitochondrial carrier protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    24310265..24312996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    24510181..24512912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    24425514..24428245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    24075387..24078118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N2J1.1 GenPept UniProtKB/Swiss-Prot:Q9N2J1

Gene LinkOut

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