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CASP3 caspase 3 [ Canis lupus familiaris (dog) ]

Gene ID: 403567, updated on 17-May-2023

Summary

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Official Symbol
CASP3provided by VGNC
Official Full Name
caspase 3provided by VGNC
Primary source
VGNC:VGNC:38734
See related
Ensembl:ENSCAFG00845015288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CASP3 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (48136012..48157278)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (46413238..46434538)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (46848704..46870015)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (46101180..46122422)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (46715535..46736806)
105 previous assembly CanFam3.1 (GCF_000002285.3) 16 NC_006598.3 (45920074..45940507)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene centromere protein U Neighboring gene uncharacterized LOC111090344 Neighboring gene primase and DNA directed polymerase Neighboring gene uncharacterized LOC119869517 Neighboring gene uncharacterized LOC119869578 Neighboring gene glutathione S-transferase P-like Neighboring gene uncharacterized LOC119869532

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Study of optimal scheme of spinal image-guided radiotherapy based on expression of caspase-3 in spinal cord neurons by orthogonal design. Xu WL, et al. Genet Mol Res, 2015 Apr 13. PMID 25966088
  2. Increased immunoreactivities of cleaved αII-spectrin and cleaved caspase-3 in the aged dog spinal cord. Hwang IK, et al. Neurochem Res, 2012 Mar. PMID 22037840
  3. Characterization of canine caspase-3. Sano J, et al. J Vet Med Sci, 2004 May. PMID 15187371
  4. Bcl-2/caspase 3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory bowel disease. Jergens A, et al. Vet Immunol Immunopathol, 2014 Apr 15. PMID 24495616
  5. Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus. Del Puerto HL, et al. Genet Mol Res, 2010 Jan 26. PMID 20198571

See all (6) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that caspase-3 expression in the spinal cord neurons was lowest when a single dose of 16 Gy was applied at a dose rate of 4 Gy/min.
    Title: Study of optimal scheme of spinal image-guided radiotherapy based on expression of caspase-3 in spinal cord neurons by orthogonal design.
  2. Mucosal imbalance of Bcl-2/caspase 3 expression favors T cell resistance to apoptosis which may contribute to T cell accumulation and chronic intestinal inflammation.
    Title: Bcl-2/caspase 3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory bowel disease.
  3. findings suggest that the increases of cleaved alphaII-spectrin and cleaved caspase-3 immunoreactivity may be related to aging of the spinal cord in dog
    Title: Increased immunoreactivities of cleaved αII-spectrin and cleaved caspase-3 in the aged dog spinal cord.
  4. The expression of Bax, Bcl-2, and caspase-3, -8 and -9, was evaluated by evaluating mRNA levels in the peripheral blood, lymph nodes and cerebellum of canine distemper virus (CDV)-infected (CDV+) and uninfected (CDV-) dogs.
    Title: Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
  
enables endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway in response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
caspase-3
Names
CASP-3
XP_038308233.1
XP_038308234.1
XP_038308235.1
XP_038308236.1
XP_038353875.1
XP_038353876.1
XP_038353877.1
XP_038353878.1
XP_038416348.1
XP_038416349.1
XP_038416350.1
XP_038416351.1
XP_038480400.1
XP_038480401.1
XP_038480402.1
XP_038546162.1
XP_038546163.1
XP_038546164.1
XP_038546165.1
XP_038546167.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419299.1 → NP_001406228.1  caspase-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000104
    UniProtKB/TrEMBL
    A0A8C0RJX4, A0A8I3NRN4

  2. NM_001419300.1 → NP_001406229.1  caspase-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000104
    UniProtKB/Swiss-Prot
    Q8MKI5
    UniProtKB/TrEMBL
    A0A8C0JL25

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    48136012..48157278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690236.1 → XP_038546164.1  caspase-3 isoform X3

    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  2. XM_038690234.1 → XP_038546162.1  caspase-3 isoform X2

    Related
    ENSCAFP00845021487.1, ENSCAFT00845027303.1
    Conserved Domains (1) summary
    smart00115
    Location:62 → 302
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  3. XM_038690239.1 → XP_038546167.1  caspase-3 isoform X1

    Conserved Domains (1) summary
    cl00042
    Location:62 → 227
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  4. XM_038690237.1 → XP_038546165.1  caspase-3 isoform X3

    UniProtKB/Swiss-Prot
    Q8MKI5
    UniProtKB/TrEMBL
    A0A8C0JL25
    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  5. XM_038690235.1 → XP_038546163.1  caspase-3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RJX4, A0A8I3NRN4
    Conserved Domains (1) summary
    smart00115
    Location:62 → 302
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    46101180..46122422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038497948.1 → XP_038353876.1  caspase-3 isoform X3

    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  2. XM_038497947.1 → XP_038353875.1  caspase-3 isoform X2

    Conserved Domains (1) summary
    smart00115
    Location:62 → 302
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  3. XM_038497950.1 → XP_038353878.1  caspase-3 isoform X1

    Conserved Domains (1) summary
    cl00042
    Location:62 → 227
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  4. XM_038497949.1 → XP_038353877.1  caspase-3 isoform X3

    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    46715535..46736806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038624473.1 → XP_038480401.1  caspase-3 isoform X3

    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  2. XM_038624472.1 → XP_038480400.1  caspase-3 isoform X2

    Conserved Domains (1) summary
    smart00115
    Location:62 → 302
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  3. XM_038624474.1 → XP_038480402.1  caspase-3 isoform X3

    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    46848704..46870015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038560422.1 → XP_038416350.1  caspase-3 isoform X3

    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  2. XM_038560420.1 → XP_038416348.1  caspase-3 isoform X2

    Conserved Domains (1) summary
    smart00115
    Location:62 → 302
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  3. XM_038560423.1 → XP_038416351.1  caspase-3 isoform X3

    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  4. XM_038560421.1 → XP_038416349.1  caspase-3 isoform X2

    Conserved Domains (1) summary
    smart00115
    Location:62 → 302
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    46413238..46434538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038452307.1 → XP_038308235.1  caspase-3 isoform X3

    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  2. XM_038452305.1 → XP_038308233.1  caspase-3 isoform X2

    Conserved Domains (1) summary
    smart00115
    Location:62 → 302
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  3. XM_038452308.1 → XP_038308236.1  caspase-3 isoform X3

    UniProtKB/Swiss-Prot
    Q8MKI5
    UniProtKB/TrEMBL
    A0A8C0JL25
    Conserved Domains (1) summary
    smart00115
    Location:37 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  4. XM_038452306.1 → XP_038308234.1  caspase-3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RJX4, A0A8I3NRN4
    Conserved Domains (1) summary
    smart00115
    Location:62 → 302
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003042.1: Suppressed sequence

    Description
    NM_001003042.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MKI5.1 GenPept UniProtKB/Swiss-Prot:Q8MKI5

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