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G6PC1 glucose-6-phosphatase catalytic subunit 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403492, updated on 25-Jul-2026
Official Symbol
G6PC1provided by VGNC
Official Full Name
glucose-6-phosphatase catalytic subunit 1provided by VGNC
Primary source
VGNC:VGNC:41040
See related
Ensembl:ENSCAFG00845006712 RGD:12418787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
G6PC; G6Pase
Orthologs
all
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Try the new Transcripts and proteins table
See G6PC1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (20851596..20862184, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (19594513..19605089, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (20005407..20015994, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (19636449..19647026, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (19902743..19913338, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene RUN domain containing 1 Neighboring gene prostaglandin E synthase 3 like Neighboring gene alanyl-tRNA editing protein Aarsd1 Neighboring gene uncharacterized LOC102154826 Neighboring gene amine oxidase copper containing 3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ. Hornbuckle LA, et al. Am J Physiol Endocrinol Metab, 2004 May. PMID 14722027
  2. Isolation and nucleotide sequence of canine glucose-6-phosphatase mRNA: identification of mutation in puppies with glycogen storage disease type Ia. Kishnani PS, et al. Biochem Mol Med, 1997 Aug. PMID 9259982
  3. Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo. Hornbuckle LA, et al. Am J Physiol Endocrinol Metab, 2001 Oct. PMID 11551847
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glucose-6-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
glucose-6-phosphatase catalytic subunit 1
Names
glucose-6-phosphatase
glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)
XP_038341382.1
XP_038403145.1
XP_038467111.1
XP_038485984.1
XP_038532300.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419280.1 → NP_001406209.1  glucose-6-phosphatase catalytic subunit 1

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000313
    UniProtKB/Swiss-Prot
    O19133
    UniProtKB/TrEMBL
    A0A8C0R019, A0A8I3MZQ1

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    20851596..20862184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676372.1 → XP_038532300.1  

    Related
    ENSCAFP00845009292.1, ENSCAFT00845011909.1
    Conserved Domains (1) summary
    cd03381
    Location:42 → 280
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    19636449..19647026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485454.1 → XP_038341382.1  

    Conserved Domains (1) summary
    cd03381
    Location:42 → 280
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    19902743..19913338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611183.1 → XP_038467111.1  

    Conserved Domains (1) summary
    cd03381
    Location:42 → 280
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    20005407..20015994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547217.1 → XP_038403145.1  glucose-6-phosphatase

    UniProtKB/Swiss-Prot
    O19133
    UniProtKB/TrEMBL
    A0A8C0R019, A0A8I3MZQ1
    Conserved Domains (1) summary
    cd03381
    Location:42 → 280
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19594513..19605089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038630056.1 → XP_038485984.1  

    Conserved Domains (1) summary
    cd03381
    Location:42 → 280
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002993.2: Suppressed sequence

    Description
    NM_001002993.2: This RefSeq was removed because there were several differences (mismatches and/or insertions and/or deletions) compared to available sequence data.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O19133.1 GenPept UniProtKB/Swiss-Prot:O19133

Gene LinkOut

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