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ABCC1 ATP binding cassette subfamily C member 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403453, updated on 5-Mar-2024

Summary

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Official Symbol
ABCC1provided by VGNC
Official Full Name
ATP binding cassette subfamily C member 1provided by VGNC
Primary source
VGNC:VGNC:54275
See related
Ensembl:ENSCAFG00845007668
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
MRP1
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
32
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (28018483..28152589, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (29219306..29353121, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (28117166..28251282, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (27821973..27955836, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (27711967..27845729, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene nodal modulator 1 Neighboring gene ATP binding cassette subfamily C member 6 Neighboring gene uncharacterized LOC111096296 Neighboring gene centrosomal protein 20 Neighboring gene myosin heavy chain 11 Neighboring gene nudE neurodevelopment protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Externalization of phosphatidylserine via multidrug resistance 1 (MDR1)/P-glycoprotein in oxalate-treated renal epithelial cells: implications for calcium oxalate urolithiasis. Li YH, et al. Int Urol Nephrol, 2016 Feb. PMID 26560472
  2. Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. Westlake CJ, et al. J Biol Chem, 2004 Dec 17. PMID 15459206
  3. Identification and characterization of the canine multidrug resistance-associated protein. Ma L, et al. Mol Cancer Ther, 2002 Dec. PMID 12516967
  4. Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells. Pawłowski KM, et al. BMC Vet Res, 2013 Jun 17. PMID 23773525, Free PMC Article
  5. ABC transporters in the eyes of dogs and implications in drug therapy. Haritova AM, et al. Curr Eye Res, 2013 Feb. PMID 23373631

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. oxalate increases the synthesis of MDR1 P-gp, which plays a key role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells.
    Title: Externalization of phosphatidylserine via multidrug resistance 1 (MDR1)/P-glycoprotein in oxalate-treated renal epithelial cells: implications for calcium oxalate urolithiasis.
  2. expression and role in multidrug resistance of mammary cancer cells
    Title: Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells.
  3. ABCC1, ABCC3 and ABCC4 are expressed predominantly in the conjunctiva and at very low levels in the cornea.
    Title: ABC transporters in the eyes of dogs and implications in drug therapy.
  4. the multidrug resistance protein 1 COOH-terminal region has elements with five conserved hydrophobic amino acids that are required for activity
    Title: Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type xenobiotic transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glutathione transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
multidrug resistance-associated protein 1
Names
ATP-binding cassette sub-family C member 1
LTC4 transporter
glutathione-S-conjugate-translocating ATPase ABCC1
leukotriene C(4) transporter
multidrug resistance protein 1
NP_001002971.1
XP_038523477.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002971.1 → NP_001002971.1  multidrug resistance-associated protein 1

    See identical proteins and their annotated locations for NP_001002971.1

    Status: PROVISIONAL

    Source sequence(s)
    AY363728
    UniProtKB/Swiss-Prot
    Q6UR05
    UniProtKB/TrEMBL
    A0A8P0NJI4
    Related
    ENSCAFP00845010609.1, ENSCAFT00845013662.1
    Conserved Domains (1) summary
    TIGR00957
    Location:7 → 1530
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    28018483..28152589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038667549.1 → XP_038523477.1  multidrug resistance-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RW12, A0A8I3N7J9
    Related
    ENSCAFP00845010905.1, ENSCAFT00845014070.1
    Conserved Domains (1) summary
    TIGR00957
    Location:7 → 1429
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RNA

  1. XR_005427955.1 RNA Sequence

    Related
    ENSCAFT00845013903.1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    27821973..27955836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    27711967..27845729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    28117166..28251282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    29219306..29353121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UR05.1 GenPept UniProtKB/Swiss-Prot:Q6UR05

Gene LinkOut

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