Format

Send to:

Choose Destination

APP amyloid beta precursor protein [ Canis lupus familiaris (dog) ]

Gene ID: 403407, updated on 13-Oct-2020

Summary

Official Symbol
APPprovided by VGNC
Official Full Name
amyloid beta precursor proteinprovided by VGNC
Primary source
VGNC:VGNC:38010
See related
Ensembl:ENSCAFG00000008557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
ABPP
Orthologs

Genomic context

See APP in Genome Data Viewer
Location:
chromosome: 31
Exon count:
18
Annotation release Status Assembly Chr Location
105 current CanFam3.1 (GCF_000002285.3) 31 NC_006613.3 (21351207..21614466, complement)

Chromosome 31 - NC_006613.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093558 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene uncharacterized LOC102151217 Neighboring gene uncharacterized LOC111093497 Neighboring gene cysteine and tyrosine rich 1

Genomic regions, transcripts, and products

Genomic Sequence:
NC_006613.3 Chromosome 31 Reference CanFam3.1 Primary Assembly

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cognition ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi-associated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
amyloid-beta A4 protein; amyloid beta A4 protein
Names
alzheimer disease amyloid A4 protein homolog
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
amyloid precursor protein
beta-amyloid precursor protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006601.2NP_001006601.2  amyloid-beta A4 protein isoform APP-770 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (APP-770).
    Source sequence(s)
    AY498706, AY926579, CO680263, DN394364, DN877827
    UniProtKB/TrEMBL
    F1P603, Q56JK6, Q6RH30
    Related
    ENSCAFP00000012583.3, ENSCAFT00000013599.5
    Conserved Domains (5) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:675713
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:716766
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
  2. NM_001293275.1NP_001280204.1  amyloid-beta A4 protein isoform APP-751 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform APP-751, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AY498708, AY926579, CO680263, DN394364, DN877827
    UniProtKB/TrEMBL
    F1P606, Q56JK6, Q6RH28
    Related
    ENSCAFP00000012580.3, ENSCAFT00000013595.5
    Conserved Domains (5) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:656694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:697747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:347529
    APP_E2; E2 domain of amyloid precursor protein
  3. NM_001293276.1NP_001280205.1  amyloid-beta A4 protein isoform APP-714 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform APP-714, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AY498706, AY498708, AY926579, AY926581, CO680263, DN394364, DN877827
    UniProtKB/TrEMBL
    F1P615, Q56JK4, Q56JK6, Q6RH28, Q6RH30
    Related
    ENSCAFP00000012578.3, ENSCAFT00000013593.5
    Conserved Domains (4) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam03494
    Location:619657
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:660710
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:310492
    APP_E2; E2 domain of amyloid precursor protein
  4. NM_001293279.1NP_001280208.1  amyloid-beta A4 protein isoform APP-695 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform APP-695, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AY498707, AY926579, CO680263, DN394364, DN877827
    UniProtKB/TrEMBL
    F1PC71, Q56JK6, Q6RH29
    Related
    ENSCAFP00000033451.2, ENSCAFT00000037829.3
    Conserved Domains (4) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam03494
    Location:600638
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:641691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:291473
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

  1. NC_006613.3 Reference CanFam3.1 Primary Assembly

    Range
    21351207..21614466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005638731.3XP_005638788.1  amyloid beta A4 protein isoform X3

    Conserved Domains (4) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam03494
    Location:582620
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:623673
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:291473
    APP_E2; E2 domain of amyloid precursor protein
  2. XM_005638728.3XP_005638785.1  amyloid beta A4 protein isoform X2

    Conserved Domains (5) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:638676
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:679729
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:347529
    APP_E2; E2 domain of amyloid precursor protein
  3. XM_005638725.3XP_005638782.1  amyloid beta A4 protein isoform X1

    Related
    ENSCAFP00000048970.1, ENSCAFT00000066450.1
    Conserved Domains (5) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:657695
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:698748
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
Support Center