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DSG1 desmoglein 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403401, updated on 27-Jun-2026
Official Symbol
DSG1provided by VGNC
Official Full Name
desmoglein 1provided by VGNC
Primary source
VGNC:VGNC:40105
See related
Ensembl:ENSCAFG00845011100 RGD:12408920
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
DSG-1
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See DSG1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (58144506..58179775, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (57597684..57630602, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (58137415..58170337, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (57822159..57855070, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (57848322..57881239, complement)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene desmoglein 3 Neighboring gene desmoglein 4 Neighboring gene uncharacterized LOC119872697 Neighboring gene transfer RNA lysine (anticodon UUU)

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A DSG1 Frameshift Variant in a Rottweiler Dog with Footpad Hyperkeratosis. Backel KA, et al. Genes (Basel), 2020 Apr 24. PMID 32344723, Free PMC Article
  2. Cloning of canine Dsg1 and evidence for alternative polyadenylation. Müller E, et al. J Invest Dermatol, 2000 Jun. PMID 10844571
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A DSG1 Frameshift Variant in a Rottweiler Dog with Footpad Hyperkeratosis.
    Title: A DSG1 Frameshift Variant in a Rottweiler Dog with Footpad Hyperkeratosis.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables gamma-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in homophilic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in desmosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
desmoglein-1
Names
DG1
DGI
desmosomal glycoprotein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002939.1 → NP_001002939.1  desmoglein-1 precursor

    See identical proteins and their annotated locations for NP_001002939.1

    Status: PROVISIONAL

    Source sequence(s)
    AF005360
    UniProtKB/Swiss-Prot
    Q9GKQ8
    UniProtKB/TrEMBL
    A0A8C0KH61
    Conserved Domains (3) summary
    cd11304
    Location:161 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:54 → 148
    Cadherin; Cadherin domain
    pfam01049
    Location:665 → 780
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    58144506..58179775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038670465.1 → XP_038526393.1  desmoglein-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KKI5, A0A8I3NIB1
    Related
    ENSCAFP00845015394.1, ENSCAFT00845019678.1
    Conserved Domains (4) summary
    cd11304
    Location:161 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:54 → 148
    Cadherin; Cadherin domain
    pfam01049
    Location:665 → 780
    Cadherin_C; Cadherin cytoplasmic region
    cl29226
    Location:276 → 377
    Cadherin; Cadherin domain

  2. XM_038670464.1 → XP_038526392.1  desmoglein-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KKI5, A0A8I3NIB1
    Conserved Domains (4) summary
    cd11304
    Location:161 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:54 → 148
    Cadherin; Cadherin domain
    pfam01049
    Location:665 → 780
    Cadherin_C; Cadherin cytoplasmic region
    cl29226
    Location:276 → 377
    Cadherin; Cadherin domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    57822159..57855070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    57848322..57881239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    58137415..58170337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    57597684..57630602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GKQ8.1 GenPept UniProtKB/Swiss-Prot:Q9GKQ8

Gene LinkOut

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