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park parkin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40336, updated on 3-Sep-2022

Summary

Official Symbol
parkprovided by FlyBase
Official Full Name
parkinprovided by FlyBase
Primary source
FLYBASE:FBgn0041100
Locus tag
Dmel_CG10523
See related
AllianceGenome:FB:FBgn0041100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAN12155.1; CG10523; Dmel\CG10523; dpark; Dpark; dParkin; dPARKIN; dpk; Park; PARK; park1; PARK2; Parkin; PARKIN; pk; PK; SD01679
Summary
Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitochondrion organization; protein ubiquitination; and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in germarium region 2b; head; oocyte; and organism. Used to study Parkinson's disease; Parkinson's disease 2; cardiomyopathy; and opportunistic bacterial infectious disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See park in Genome Data Viewer
Location:
78C2-78C2; 3-47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21194754..21196853, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21187854..21189953, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Asparagine synthetase Neighboring gene chromosome bows Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45951 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in larval locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of mitochondrial fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy of mitochondrion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of compound eye pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
parkin
Names
CG10523-PB
CG10523-PC
D-parkin
dparkin
park-PB
park-PC
parkin F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21194754..21196853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168884.2NP_730600.1  parkin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TI4
    UniProtKB/TrEMBL
    Q7KTX7
    Related
    FBpp0077974, FBtr0078318
    Conserved Domains (5) summary
    smart00647
    Location:334390
    IBR; In Between Ring fingers
    cd01798
    Location:32105
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
    pfam01485
    Location:435471
    IBR; IBR domain, a half RING-finger domain
    pfam17978
    Location:249339
    zf-RING_14; RING/Ubox like zinc-binding domain
    cd21382
    Location:159250
    RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
  2. NM_168885.3NP_730601.1  parkin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730601.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TI4
    UniProtKB/TrEMBL
    Q7KTX7
    Related
    FBpp0077975, FBtr0078319
    Conserved Domains (5) summary
    smart00647
    Location:334390
    IBR; In Between Ring fingers
    cd01798
    Location:32105
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
    pfam01485
    Location:435471
    IBR; IBR domain, a half RING-finger domain
    pfam17978
    Location:249339
    zf-RING_14; RING/Ubox like zinc-binding domain
    cd21382
    Location:159250
    RING0_parkin; RING finger-like zinc-binding domain 0 of parkin